משלוחים לרחבי הארץ

Fong KC, Kinnear PE. Retrobulbar haemorrhage

associated with chronic Ginkgo bilobaingestion. Postgrad Med J 2003;79:531-

532. https://www.ncbi.nlm.nih.gov/pubmed/13679551


Rosenblatt M, Mindel J. Spontaneous Hyphema Associated with Ingestion of Ginkgo biloba Extract N Engl J Med. 1997 Apr 10;336(15):1108. https://www.ncbi.nlm.nih.gov/pubme

d/9091822


Carlile PV. Unexplained alveolar hemorrhage associated with Ginkgo and ginseng use. J Bronchology Interv Pulmonol, 2015;22:170-172. https://www.ncbi.nlm.nih.gov/pubmed/25887018


Bone KM. Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence? Mol Nutr Food Res. 2008 Jul;52(7):764-71. https://www.ncbi.nlm.nih.gov/pubmed/18214851


Ernst E, Canter PH, Coon JT. Does Ginkgo biloba increase the risk of bleeding? A systemic review of case reports. Perfusion 2005; 18: 52-6 https://www.researchgate.net/publication/286867621


Guinot P, Caffrey E, Lambe R, Darragh A. Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers. Haemostasis. 1989;19(4):219-23. https://www.ncbi.nlm.nih.gov/pubmed/2807039


Chung KF, Dent G, McCusker M, et al. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet. 1987;1:248–51. https://www.ncbi.nlm.nih.gov/pubmed/2880069


Braquet P, Touqui L, Shen TY, Vargaftig BB. Perspectives in platelet-activating factor research. Pharmacol Rev. 1987 Jun;39(2):97-145. https://www.ncbi.nlm.nih.gov/pubmed/3303066


Braquet P. Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. Adv Prostaglandin Thromboxane Leukot Res. 1986;16:179-98. https://www.ncbi.nlm.nih.gov/pubmed/2949548


DeFeudis FV, Drieu K. Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Curr Drug Targets 2000; Jul;1(1):25-58. https://www.ncbi.nlm.nih.gov/pubmed/11475535


Kudolo GB. Arachidonic Acid and Platelet-Activating Factor as Central Players in the metabolic syndrome. Lessons from the Use of the Ginkgo biloba Extract. EC Pharmacology and Toxicology. 2.4 (2016): 208-217. https://www.ecronicon.com/ecpt/pdf/ECPT-02-000030.pdf


Kudolo GB, Dorsey S, Blodgett J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. Thromb Res. 2002 Nov 1;108(2-3):151-60. https://www.ncbi.nlm.nih.gov/pubmed/12590952


Kudolo GB, Delaney D, Blodgett J. Short-term oral ingestion of Ginkgo biloba extract (EGb 761) reduces malondialdehyde levels in washed platelets of type 2 diabetic subjects. Diabetes Res Clin Pract. 2005 Apr;68(1):29-38. https://www.ncbi.nlm.nih.gov/pubmed/15811563


Kudolo GB, Wang W, Dorsey S, Blodgett J. Oral ingestion of Ginkgo biloba extract reduces thiobarbituric acid reacting (TBAR) substances in washed platelets of healthy subjects. J Herb Pharmacother. 2003;3(4):1-15. https://www.ncbi.nlm.nih.gov/pubmed/15277117


Kudolo GB, Wang W, Barrientos J, Elrod R, Blodgett J.The ingestion of Ginkgo biloba extract (EGb 761) inhibits arachidonic acid-mediated platelet aggregation and thromboxane B2 production in healthy volunteers. J Herb Pharmacother. 2004;4(4):13-26. https://www.ncbi.nlm.nih.gov/pubmed/15927922


Savovic’ J, Wider B, Ernst E. Effects of Ginkgo biloba on blood coagulation parameters: a systematic review of randomised clinical trials. Evid Based Integrative Med 2005; 2: 167-76. https://www.ncbi.nlm.nih.gov/books/NBK71867/


Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy. 2011 May;31(5):490-502. https://www.ncbi.nlm.nih.gov/pubmed/21923430


Kohler S, Funk P, Kieser M. Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers. Blood Coagul Fibrinolysis 2004;15:303-309. https://www.ncbi.nlm.nih.gov/pubmed/15166915


Bal Dit Sollier C, Caplain H, Drouet L. No alteration in platelet function or coagulation induced by EGB761 in a controlled study. Clin Lab Haematol 2003;25:251-253. https://www.ncbi.nlm.nih.gov/pubmed/12890165


Jiang X, Williams KM, Liauw WS et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005;59:425-432. https://www.ncbi.nlm.nih.gov/pubmed/15801937


Kudolo GB. Effect of Ginkgo biloba Extract Ingestion on Plasma Total Cortisol Levels During An Oral Glucose Tolerance Test in Normal Glucose Tolerant Individuals. Food and Nutrition Sciences, 2014, 5: 1561-1567. https://pdfs.semanticscholar.org/8aB5/dfbf2b1f88a4dfbef39a7efc84e029B7cb42.pdf


Halil M, Cankurtaran M, Yavuz BB, et al. No alteration in the PFA-100 in vitro bleeding time induced by the Ginkgo biloba special extract, EGb 761, in elderly patients with mild cognitive impairment. Blood Coagul Fibrinolysis. 2005;16(5):349–353. https://www.ncbi.nlm.nih.gov/pubmed/15970719


Schneider LS, DeKosky ST, Farlow MR, et al. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr Alzheimer Res. 2005;2:541–51. https://www.ncbi.nlm.nih.gov/pubmed/16375657


Horsch S, Walther C. Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD)--a review based on randomized, controlled studies. Int J Clin Pharmacol Ther. 2004;42(2):63–72. https://www.ncbi.nlm.nih.gov/pubmed/15180165


Brinker F. Herb Contraindications and Drug Interactions, 4th ed. Sandy (OR): Eclectic Medical Publications; 2010 https://www.eclecticherb.com/herb-contraindications-drug-interactions


McGuffin M, Hobbs C, Upton R, Goldberg A (eds). American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997 https://www.crcpress.com/American-Herbal-Products-Associations-Botanical-Safety-Handbook/Gardner-McGuffin/p/book/9781466516946


Chan AL, Leung HW, Wu JW, et al. Risk of hemorrhage associated with co-prescriptions for Ginkgo biloba and antiplatelet or anticoagularnt drugs. J Altern Complement Med. 2011;17(6): 513–517. https://www.ncbi.nlm.nih.gov/pubmed/21649517

Murphy JM. Preoperative considerations with herbal medicines. Assoc. Operat. Room Nurses J., 69(1):173-183, 1999 https://www.ncbi.nlm.nih.gov/pubmed/9932176


Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA, 286(2):208-216, 2001. https://www.ncbi.nlm.nih.gov/pubmed/11448284

Norred CL, Finlayson CA. Hemorrhage after the preoperative use of complementary and alternative medicines. Am. Assoc. Nurse Anesthes. J., 68(3):217-220, 2000 https://pdfs.semanticscholar.org/c543/dB6a8ded5bbde8f11665cc59183d60d82ce3.pdf

Assemi M. Herbal preparations: concerns for operative patients. Anesthesia Today, 10(3):17-23, 2000.

Destro MWB, Speranzini MB, Cavalheiro Filho C, et al. Bilateral haematoma after rhytidoplasty and blepharoplasty following chronic use of Ginkgo biloba. Br. Assoc. Plat. Surg., 58:100-101, 2005 https://www.ncbi.nlm.nih.gov/pubmed/15629177

Some Drugs and Herbal Products. International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 108, 2013:91-112. https://monographs.iarc.fr/ENG/Monographs/vol108/mono108-03.pdf

Biggs M, Sorkin B, Nahin R, Kuller L, Fitzpatrick A. Ginkgo biloba and risk of cancer: secondary analysis of the Ginkgo Evaluation of Memory (GEM) Study. Pharmacoepidemiol Drug Saf, 2010;19:694-698. https://www.ncbi.nlm.nih.gov/pubmed/20582906

Bonassi S, Prinzi G, Lamonaca P, et al. Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect®Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx]. BMC Complement Altern Med. 2018 Jan 22;18(1):22. https://www.ncbi.nlm.nih.gov/pubmed/29357859

Brasky TM, Lampe JW, Potter JD, Patterson RE, White E. Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort. Cancer Epidemiol Biomarkers Prev, 2010;19(7):1696–708. doi:10.1158/1055-9965.EPI-10-0318 PMID:20615886 https://www.ncbi.nlm.nih.gov/pubmed/20615886

Brasky TM, Kristal AR, Navarro SL, Lampe JW, Peters U, Patterson RE, et al. Specialty supplements and prostate cancer risk in the VITamins and Lifestyle. Nutr Cancer. 2011;63(4):573-82. https://www.ncbi.nlm.nih.gov/pubmed/21598177

Hotaling JM, Wright JL, Pocobelli G, Bhatti P, Porter MP, White E. Long-term use of supplemental vitamins and minerals does not reduce the risk of urothelial cell carcinoma of the bladder in the Vitamins and Lifestyle study. J Urol. 2011;185(4):1210–5. https://www.ncbi.nlm.nih.gov/pubmed/21334017

Satia JA, Littman A, Slatore CG, Galanko JA, White E. Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1419–28. https://www.ncbi.nlm.nih.gov/pubmed/19423520

Ye B, Aponte M, Dai Y, Li L, Ho MC, Vitonis A et al. Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Lett. 2007;251(1):43–52. https://www.ncbi.nlm.nih.gov/pubmed/17194528

Mei N, Guo X, Ren Z, Kobayashi D, Wada K, Guo L. Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports, J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017 Jan 2;35(1):1-28. https://www.ncbi.nlm.nih.gov/pubmed/28055331

Wada K. Ginkgo seed food poisoning. Chudoku Kenkyu, 2005;18:11-16. https://www.researchgate.net/publication/7893941

Miwa H, Iijima M, Tanaka S, Mizuno Y. Generalized convulsions after consuming a large amount of Ginkgo nuts. Epilepsia, 2001;42:280-281. https://www.ncbi.nlm.nih.gov/pubmed/11240603

Hasegawa S, Oda Y, Ichiyama T, Hori Y, Furukawa S. Ginkgo nut intoxication in a 2- year-old male. Pediatr Neurol, 2006;35:275-276. https://www.ncbi.nlm.nih.gov/pubmed/16996402

Hori Y, Fujisawa M, Shimada K, Oda A, Katsuyama S, Wada K. Rapid analysis of 4-Omethylpyridoxine in the serum of patients with Ginkgo biloba seed poisoning by ion-pair high-performance liquid chromatography. Biol Pharm Bull, 2004;27:486-491. https://www.ncbi.nlm.nih.gov/pubmed/15056852

Di Lorenzo C, Ceschi A, Colombo F, et al. Identification and quantification of biomarkers toconfirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy. Toxicol Res, 2015;4:922-930. https://www.researchgate.net/publication/273520847

Kajiyama Y, Fujii K, Takeuchi H, Manabe Y. Ginkgo seed poisoning. Pediatrics, 2002;109:325-327. https://www.ncbi.nlm.nih.gov/pubmed/11826216

Wada K, Ishigaki S, Ueda K, Sakata M, Haga M. An antivitamin B6, 4'- methoxypyridoxine, from the seed of Ginkgo biloba L. Chem Pharm Bull (Tokyo), 1985;33:3555-3557. https://www.ncbi.nlm.nih.gov/pubmed/4085085

Jang HS, Roh SY, Jeong EH, Kim BS, Sunwoo MK. Ginkgotoxin Induced Seizure Caused by Vitamin B6 Deficiency. J Epilepsy Res, 2015;5:104-106. https://www.ncbi.nlm.nih.gov/pubmed/26819944

Bonvoison B, Guinot P. In: Braquet P, ed. Ginkgolides – Chemistry, Biology, Pharmacology and Clinical Perspectives, vol. 1. Barcelona, JR: Prous Science Publishers; 1989. pp. 845–854. https://www.abebooks.com/Ginkgolides-Chemistry-Biology-Pharmacology-Clinical-Perspectives/3989812028/bd

Lieberman HR, Kellogg MD, Fulgoni VL, Agarwal S. Moderate doses of commercial preparations of Ginkgo biloba do not alter markers of liver function but moderate alcohol intake does: A new approach to identify and quantify biomarkers of 'adverse effects' of dietary supplements. Regul Toxicol Pharmacol. 2017 Mar;84:45-53. https://www.ncbi.nlm.nih.gov/pubmed/28025058

Blaschek W, Ebel S, Hackenthal E, et al. HagerROM 2002: Hagers Handbuch der Drogen und Arzneistoffe. Heidelberg: Springer; 2002. https://www.springer.com/de/book/9783540282334

Spinella M, Eaton LA. Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury. Brain Inj. 2002;16(4):359–367. https://www.ncbi.nlm.nih.gov/pubmed/11953006

Wang H, Wu X, Lezmi S, Li Q, Helferich WG, Xu Y, et al. Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model. BMC Complement Altern Med. 2017 Dec 2;17(1):516. https://www.ncbi.nlm.nih.gov/pubmed/29197355

National Toxicology Program.Toxicology and carcinogenesis studies of Ginkgo biloba extract (CAS No. 90045-36-6) in F344/N rats and Bִ6C3F1/N mice (Gavage studies). Natl Toxicol Program Tech Rep Ser. 2013 Mar;(578):1-183. https://www.ncbi.nlm.nih.gov/pubmed/23652021

Zhang Z, Chen S, Mei H, Xuan J, Guo X, Couch L, Dobrovolsky VN, Guo L, Mei N. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Sci Rep, 2015;5:14633. https://www.ncbi.nlm.nih.gov/pubmed/26419945

He J, Lin J, Li J, Zhang JH, Sun XM, Zeng CM. Dual effects of Ginkgo biloba leaf extract on human red blood cells. Basic Clin Pharmacol Toxicol, 2009;104:138-144. https://www.ncbi.nlm.nih.gov/pubmed/19143753

Chao JC, Chu CC. Effects of Ginkgo biloba extract on cell proliferation and cytotoxicity in human hepatocellular carcinoma cells. World J Gastroenterol, 2004;10:37- 41. https://www.ncbi.nlm.nih.gov/pubmed/14695765

Kim KS, Rhee KH, Yoon JH, Lee JG, Lee JH and Yoo JB. Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. Oral Oncol, 2005;41:383-389. https://www.ncbi.nlm.nih.gov/pubmed/15792610

Babich H, Ackerman NJ, Burekhovich F, Zuckerbraun HL, Schuck AG. Ginkgo biloba leaf extract induces oxidative stress in carcinoma HSC-2 cells. Toxicol In Vitro, 2009;23:992-999. https://www.ncbi.nlm.nih.gov/pubmed/19560534

Lin H, Guo X, Zhang S, Dial SL, Guo L, Manjanatha MG, Moore MM, Mei N. Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells. Toxicol Sci, 2014;139:338-349. https://www.ncbi.nlm.nih.gov/pubmed/24595819

Haefeli WE, Carls A. Drug interactions with phytotherapeutics in oncology. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):359-77. https://www.ncbi.nlm.nih.gov/pubmed/24387348

Yang XF, Wang NP, Lu WH, Zeng FD. Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats. Acta Pharmacol Sin. 2003;24:1033–1038. https://www.ncbi.nlm.nih.gov/pubmed/14531948

Taki Y, Yokotani K, Yamada S, Shinozuka K, et al. Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice. Phytomedicine,2012;2:177-182. https://www.ncbi.nlm.nih.gov/pubmed/21802929

Shinozuka K, Umegaki K, Kubota Y, et al. Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci. 2002;70:2783–2792. https://www.ncbi.nlm.nih.gov/pubmed/12269382

Zhao LZ, Huang M, Chen J, et al. Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats. Curr Drug Metab. 2006 Aug;7(6):577-87. https://www.ncbi.nlm.nih.gov/pubmed/16918313

Chatterjee SS, Doelman CJ, Noldner M, et al. Influence of the Ginkgo extract EGb 761 on rat liver cytochrome P450 and steroid metabolism and excretion in rats and man. J Pharm Pharmacol. 2005 May;57(5):641-50. https://www.ncbi.nlm.nih.gov/pubmed/15901353

Gurley BJ, Gardner SF, Hubbard MA et al. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John’s wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging 2005 https://www.ncbi.nlm.nih.gov/pubmed/15974642


מקורות מחקריים:

[1] Yu-Zhou Wu 1Shu-Qin LiXiu-Guang Zu et al. Ginkgo biloba extract improves coronary artery circulation in patients with coronary artery disease: contribution of plasma nitric oxide and endothelin-1. Phytother Res. 2008 Jun;22(6):734-9. PMID: 18446847. DOI: 10.1002/ptr.2335


[2] Yinfeng YangYan LiJinghui Wang et al. Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model. ACS Chem Biol. 2017 May 19;12(5):1363-1372. PMID: 28333443. DOI: 10.1021/acschembio.6b00762


[3] Guoyan YangYuyi WangJin SunKang ZhangJianping Liu. Ginkgo Biloba for Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Curr Top Med Chem. 2016;16(5):520-8. PMID: 26268332. DOI: 10.2174/1568026615666150813143520


[4] H WoelkK H ArnoldtM KieserR Hoerr. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J Psychiatr Res. 2007 Sep;41(6):472-80. PMID: 16808927. DOI: 10.1016/j.jpsychires.2006.05.004


[5] Xiao ChuXinxin CiJiakang HeMiaomiao Wei et al. A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway. Molecules. 2011 Sep 6;16(9):7634-48. PMID: 21900866. PMCID: PMC6264276. DOI: 10.3390/molecules16097634


[6] Yong CaiRong ShiHuijiang Song et al. Effects of Lung Support Formula on respiratory symptoms among older adults: results of a three-month follow-up study in Shanghai, China. Nutr J. 2013 May 6;12:57. PMID: 23641817. PMCID: PMC3698174. DOI: 10.1186/1475-2891-12-57


[7] Yu-Yun ChangYueh-Ting TsaiJung-Nien Lai et al. The traditional Chinese medicine prescription patterns for migraine patients in Taiwan: a population-based study. J Ethnopharmacol. 2014 Feb 12;151(3):1209-1217. PMID: 24389028. DOI: 10.1016/j.jep.2013.12.040

 

Schwabe U, Paffrath D. Arzneiverordnungs-Report, 2000. https://link.springer.com/book/10.1007/978-3-

642-56832-9


Pennisi RS. Acute generalised exanthematous pustulosis induced by the herbal remedy Ginkgo biloba.

Med J Aust, 2006;184:583-584. https://www.ncbi.nlm.nih.gov/pubmed/16768668


Hotta E, Tamagawa-Mineoka R, Katoh N. Allergic contact dermatitis due to ginkgo tree fruit and leaf. Eur J Dermatol, 2013;23:548-549. https://www.ncbi.nlm.nih.gov/pubmed/23965545


Mills S, Bone K. Principles and practice of Phytotherapy. Modern Herbal Medicine, 2ed. Churchill Livingstone, 2013. . https://www.elsevier.com/books/principles-and-practice-of-phytotherapy/9780443069925


DeFeudis FV. Ginkgo Biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications. Amsterdam: Elsevier; 1991. pp. 143–146. https://www.cell.com/trends/pharmacological-sciences/fulltext/0165-6147(92)90102-C


Mossabeb R, Kraft D, Valenta R. Evaluation of the allergenic potential of Ginkgo biloba extracts. Wien Klin Wochenschr. 2001;113(15–16):580–587. https://www.ncbi.nlm.nih.gov/pubmed/11571835


Pittler MH, Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am J Med. 2000;108(4):276–281. https://www.ncbi.nlm.nih.gov/pubmed/11014719


Woerdenbag HJ, Van Beek TA. In: De Smet PAGM, Keller K, Hansel R et al, eds. Adverse Effects of Herbal Drugs, vol. 3. Berlin: Springer-Verlag; 1997. pp. 57–60. https://link.springer.com/book/10.1007%2F978-3-642-60367-9


Ernst E, Pittler MH. Ginkgo biloba for dementia: a systematic review of double-blind placebo controlled trials. Clin Drug Invest. 1999;4:301–308. https://www.researchgate.net/publication/233554846


Heinonen T, Gaus W. Cross matching observations on toxicological and clinical data for the assessment of tolerability and safety of Ginkgo biloba leaf extract. Toxicology. 2014 Nov 11. j.tox.2014.10.013. https://www.ncbi.nlm.nih.gov/pubmed/25446328


Le Bars PL, Kastelan J. Efficacy and safety of a Ginkgo biloba extract. Public Health Nutr. 2000;3(4A):495–499. https://www.ncbi.nlm.nih.gov/pubmed/11276297

Birks J, Grimley EV, Van Dongen M. Ginkgo biloba for cognitive impairment and dementia. Cochran


Database Syst Rev. 2002;4:CD003120. https://www.ncbi.nlm.nih.gov/pubmed/12519586


Cianfrocca C, Pelliccia F, Auriti A, Santini M. Ginkgo biloba-induced frequent ventricular arrhythmia. It

Heart J, 2002;3:689-691. https://www.researchgate.net/publication/10968742


Russo V, Rago A, Russo GM, Calabro R, Nigro G. Ginkgo biloba: an ancient tree with new arrhythmic side

effects. J Postgrad Med, 2011;57:221. http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2011;volume=57;issue=3;spage=221;epage=221;aulast=Russo


German Commission E monograph, Trockenextrakt (35–67:1) aus Ginkgo-biloba-Blättern Extrakt mit Aceton-Wasser. Bundesanzeiger, 1994, 46:7361–7362. https://www.heilpflanzen-welt.de/1994-07-Trockenextrakt-35-67-1-aus-Ginkgo-biloba-Blaettern-extrahiert-mit-Aceton-Wasser/


Hoban CL, Byard RW, Musgrave IF. Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015. J Integr Med. 2019 Sep;17(5):338-343. https://www.ncbi.nlm.nih.gov/pubmed/31113761


Arzneimittelkommission der deutschen Ärzteschaft Dtsch Ärztebl. 2000;97(8):A474. https://www.aerzteblatt.de/archiv/21356/Arznei%C2%ADmittel%C2%ADkommission-der-deutschen-Aerzteschaft-Aus-der-UAW-Datenbank-Ginkgo-Praeparate-Nebenwirkungsprofil


Arzneimittelkommission der deutschen Ärzteschaft. Dtsch Ärztebl. 2002;99(33):A2214. https://www.aerzteblatt.de/archiv/32658/Mitteilungen-Aus-der-UAW-Datenbank


Davydov L, Stirling AL. Stevens-Johnson Syndrome with Ginkgo Biloba. J Herbal Pharmacother. 2001;1(3):65–69. https://www.tandfonline.com/doi/abs/10.1080/J157v01n03_06


Dodge HH, Zitzelberger T, Oken BS, Howieson D, Kaye J. A randomized placebo controlled trial of Ginkgo biloba for the prevention of cognitive decline. Neurology, 2008;70:1809-1817. https://www.ncbi.nlm.nih.gov/pubmed/18305231


Fessenden JM, Wittenborn W, Clarke L. Ginkgo biloba: a case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am Surg. 2001;67(1):33–35. https://www.ncbi.nlm.nih.gov/pubmed/11206893


Bent S, Goldberg H, Padula A, Avins AL. Spontaneous bleeding associated with ginkgo biloba: a case report and systematic review of the literature: a case report and systematic review of the literature. J Gen Intern Med. 2005;20:657–61. https://www.ncbi.nlm.nih.gov/pubmed/16050865


Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996;46:1775-1776. https://www.ncbi.nlm.nih.gov/pubmed/8649594


Gilbert GJ. Ginkgo biloba.Neurology. 1997;48(4):1137. https://www.ncbi.nlm.nih.gov/pubmed/9109922

Vale S. Subarachnoid haemorrhage associated with Ginkgo biloba [letter]. Lancet 1998;352. https://www.ncbi.nlm.nih.gov/pubmed/9800751


Benjamin J, Muir T, Briggs K, et al. A case of cerebral haemorrhage – can Ginkgo biloba be implicated? Postgrad. Med. J., 77:112-113, 2001 https://www.ncbi.nlm.nih.gov/pubmed/11161079


Purroy Garcia F, Molina C, Alvarez Sabin. Hemorragia cerebelosa esponetanea asociade a la ingestion de Ginkgo biloba. J. Med Clin (Barc). 2002;119(15): 596–597. https://www.researchgate.net/publication/288329890


Miller LG, Freeman B. Possible subdural hematoma associated with Ginkgo biloba. J. Herbal Pharmacother., 2002;2(2):57-63. https://www.ncbi.nlm.nih.gov/pubmed/15277097


Schneider C, Bord C, Misse P, et al. Hyphema spontane provoque par l’extrait de Ginkgo biloba. J Fr Ophtalmol. 2002;25(7):731–732. https://www.em-consulte.com/en/article/112446


Griffiths J, Jordon S, Pilon K. Canadian Adverse Reaction Newsletter. 2004;14(1):2–3. https://www.canada.ca/content/dam/hc-sc/migration/hc-sc/dhp-mps/alt_formats/pdf/medeff/bulletin/carn-bcei_v14n1-eng.pdf


Pedroso JL, Henriques Aquino CC, Escórcio Bezerra ML, et al. Ginkgo biloba and cerebral bleeding: a case report and critical review. Neurologist. 2011;17(2):89–90. https://www.ncbi.nlm.nih.gov/pubmed/21364361


Gurley BJ, Gardner SF, Hubbard MA et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002 https://www.ncbi.nlm.nih.gov/pubmed/12235448

Zadoyan G, Rokitta D, Klement S, Dienel A, Hoerr R, Gramatté T, et al. Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: A cocktail interaction study in healthy volunteers. Eur J Clin Pharmacol. 2012 May;68(5):553-60. https://www.ncbi.nlm.nih.gov/pubmed/22189672

Duche JC, Barre J, Guinot P. et al. Effect of Ginkgo biloba extract on microsomal enzyme induction. Int J Clin Pharmacol Res. 1989;9(3):165-8. https://www.ncbi.nlm.nih.gov/pubmed/2744909

Yasui-Furukori N, Furukori H, Kaneda A, et al. The effects of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil. J Clin Pharmacol. 2004 May;44(5):538-42. https://www.ncbi.nlm.nih.gov/pubmed/15102875

Deng Y, Bi HC, Zhao LZ, et al. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica. 2008a;38:465–481. https://www.ncbi.nlm.nih.gov/pubmed/18421621

Tang J, Sun J, Zhang Y, et al. (2007). Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats. Food Chem Toxicol. 2007 Dec;45(12):2441-5. https://www.ncbi.nlm.nih.gov/pubmed/17681658

Gaudineau C, Beckerman R, Welbourn S, Auclair K. Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochem Biophys Res Commun. 2004;318:1072–1078. https://www.ncbi.nlm.nih.gov/pubmed/15147983

Vardy J, Dhillon HM, Clarke SJ, et al. Investigation of herb-drug interactions with ginkgo biloba in women receiving hormonal treatment for early breast cancer. Springer Plus 2013;2:126. https://www.ncbi.nlm.nih.gov/pubmed/23596562

Markowitz JS, Donovan JL, DeVane CL, Sipkes L, Chavin KD. Multiple Dose Administration of Ginkgo biloba Did Not Affect Cytochrome P-450 2D6 or 3A4 Activity in Normal Volunteers. J Clin Psychopharmacol. 2003 Dec;23(6):576-81. https://www.ncbi.nlm.nih.gov/pubmed/14624188

Choi JG, Eom SM, Kim J, et al., A Comprehensive Review of Recent Studies on Herb-Drug Interaction: A Focus on Pharmacodynamic Interaction. J Altern Complement Med. 2016 Apr;22(4):262-79. https://www.ncbi.nlm.nih.gov/pubmed/27003511

Uchida S, Yamada H, Li XD, et al. Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. J. Clin. Pharmacol., 2006, 46:1290- 1298, https://www.ncbi.nlm.nih.gov/pubmed/17050793

Smith M, Lin KM, Zheng YP. An open trial of nifedipine-herb interactions: nifedipine with St. John's wort, ginseng or Ginko [sic] biloba. Clin. Pharmacol. Ther. 2001;69(2):P86. https://eurekamag.com/research/034/395/034395081.php

Robertson SM, Davey RT, Voell J, et al. Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in health subjects. Curr. Med. Res. Opion., 2008, 24(2):591-599. https://www.tandfonline.com/doi/abs/10.1185/030079908x260871

Naccarato M, Yoong D, Gough K. A Potential Drug-Herbal Interaction between Ginkgo biloba and Efavirenz. J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):98-100. https://www.ncbi.nlm.nih.gov/pubmed/22323244

Yang CY, Chao PDL, Hou YC, et al. Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats. Food Chem Toxicol. 2006 Sep;44(9):1572–8. https://www.ncbi.nlm.nih.gov/pubmed/16762474

Ren Y, Li H, Liu X. Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats. Pharm Biol. 2019 Dec;57(1):403–6. https://www.ncbi.nlm.nih.gov/pubmed/31188698

Sprouse AA, van Breemen RB. Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements. Drug Metab Dispos. 2016 Feb;44(2):162-71. https://www.ncbi.nlm.nih.gov/pubmed/26438626

Rehman SU, Choi MS, Choe K, Yoo HH. Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management. Arch Pharm Res. 2015 Jul;38(7):1281-98. https://www.ncbi.nlm.nih.gov/pubmed/25475096

Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med. 2005;11:433–439. https://www.ncbi.nlm.nih.gov/pubmed/15992226

Etheridge A, Black S, Patel P, et al. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Medica. 2007;73:731–741. https://www.ncbi.nlm.nih.gov/pubmed/17611934

Ohnishi N, Kusuhara M, Yoshioka M, et al. Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf 22 extract on the pharmacokinetics of diltiazem in rats. Biol Pharm Bull. 2003 Sep;26(9):1315-20. https://www.ncbi.nlm.nih.gov/pubmed/12951478

He N, Cai HB, Xie HG, et al. Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B. Clin Exp Pharmacol Physiol. 2007;34:632–635. https://www.ncbi.nlm.nih.gov/pubmed/17581220

Deng Y, Bi H, Zhao L, Wang X, Chen J, Ou Z, et al. Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes. Drug Metab Lett. 2008 Jan;2(1):60–6. https://www.ncbi.nlm.nih.gov/pubmed/19356072

Rajaraman G, Chen J, Chang TK. Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol. 2006 Dec 1;217(2):225-33. https://www.ncbi.nlm.nih.gov/pubmed/17045319

Chang TK, Chen J, Yeung EY. Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: Identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. Toxicol Appl Pharmacol. 2006a;213:18–26. https://www.ncbi.nlm.nih.gov/pubmed/16226778

Umegaki K, Saito K, Kubota Y, et al. Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats. Jpn J Pharmacol. 2002;90:345–351. https://www.jstage.jst.go.jp/article/jjp/90/4/90_4_345/_pdf

Lau AJ, Chang TK. Inhibition of human CYP2Bִ6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: Effect of terpene trilactones and flavonols. Drug Metab Dispos. 2009 Sep;37(9):1931-7. https://www.ncbi.nlm.nih.gov/pubmed/19487249

Mohutsky MA, Anderson GD, Miller JW, Elmer GW. Ginkgo biloba: Evaluation of CYP2C9 drug interactions in vitro and in vivo. Am J Ther. 2006;13:24–31. https://www.ncbi.nlm.nih.gov/pubmed/16428919

Greenblatt DJ, von Moltke LL, Luo Y et al. Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate. J Clin Pharmacol. 2006 Feb;46(2):214-21. https://www.ncbi.nlm.nih.gov/pubmed/16432273

Sugiyama T, Kubota Y, Shinozuka K, et al. Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats. Life Sci. 2004 Jul 16;75(9):1113–22. https://www.ncbi.nlm.nih.gov/pubmed/15207658

Lei HP, Wang G, Wang LS, Ou-yang DS, Chen H, Li Q, Zhang W, Tan ZR, Fan L, He YJ, Zhou HH. Lack of effect of Ginkgo biloba on voriconazole pharmacokinetics in Chinese volunteers identified as CYP2C19 poor and extensive metabolizers. Ann Pharmacother. 2009 Apr;43(4):726-31. Epub 2009 Mar 18. https://www.ncbi.nlm.nih.gov/pubmed/19299322

Zuo XC, Zhang BK, Jia SJ, et al. Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects. Eur J Clin Pharmacol. 2010;66(5):503–509. https://www.ncbi.nlm.nih.gov/pubmed/20186406

Yin OQ, Tomlinson B, Waye MM, et al. Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics. 2004;14(12):841–850. https://www.ncbi.nlm.nih.gov/pubmed/15608563

Colalto C. Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment. Pharmacol Res. 2010;62(3):207–227. https://www.ncbi.nlm.nih.gov/pubmed/20399862

Fan L, Tao GT, Wang G, et al. Effects of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers. Ann. Pharmacother. 2009;43:944-949. https://www.ncbi.nlm.nih.gov/pubmed/19401473

Fan L, Mao XQ, Tao GY, et al. Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. Xenobiot. 2009;39(3):249-254. https://www.ncbi.nlm.nih.gov/pubmed/19280523

Mauro VF, Mauro LS, Kleshinski JF, et al. Impact of Ginkgo biloba on the pharmacokinetics of digoxin. Am J. Therapeut. 2003;10(4):247-251. https://www.ncbi.nlm.nih.gov/pubmed/12845387

Gurley BJ, Fifer EK, Gardner Z. Pharmacokinetic herb-drug interactions (part2): drug interactions involving popular botancial dietary supplements and their clinical relevance. Planta Med. 2012 Sep;78(13):1490-514. https://www.ncbi.nlm.nih.gov/pubmed/22565299

Lu WJ, Huang JD, Lai ML. The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine. J Clin Pharmacol. 2006;46(6):628–634. https://www.ncbi.nlm.nih.gov/pubmed/16707409

Fuchikami H, Satoh H, Tsujimoto M, et al. Effects of herbal extracts on the function of human organic aniontransporting polypeptide OATP-B. Drug Metab Dispos. 2006;34:577–582. https://www.ncbi.nlm.nih.gov/pubmed/16415120

Mohamed ME, Frye RF. Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids. Drug Metab Dispos. 2010;38:270–275. https://www.ncbi.nlm.nih.gov/pubmed/19889883

Stargrove MB, Treasure J, McKee D. Herb, Nutrient, and Drug Interactions, Elsevier, 2008. https://www.us.elsevierhealth.com/herb-nutrient-and-drug-interactions-9780323029643.html

Wada K, Sasaki K, Miura K et al. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull 1993;16:210-212. https://www.ncbi.nlm.nih.gov/pubmed/8364459

Brochet D, Chermat R, DeFeudis FV, Drieu K. Effects of single intraperitoneal injections of an extract of Ginkgo biloba (EGb 761) and its terpene trilactone constituents on barbital-induced narcosis in the mouse. Gen Pharmacol. 1999 Sep;33(3):249–56. https://www.ncbi.nlm.nih.gov/pubmed/10480658

Kubota Y, Kobayashi K, Tanaka N, et al. Pretreatment with Ginkgo biloba extract weakens the hypnosis action of phenobarbital and its plasma concentration in rats. J Pharm Pharmacol 2004:56:401–405. https://www.ncbi.nlm.nih.gov/pubmed/15025867

Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost. 2002;87:1075–6. https://www.ncbi.nlm.nih.gov/pubmed/12083489

DeLoughery TG, Kaye JA, Morris CD, et al. Ginkgo Biloba Does Not Affect Platelet Function in Elderly Patients. Blood. 2002;100(11). https://eurekamag.com/research/034/993/034993974.php

Li S, Zhang X, Fang Q, et al. Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial. Stroke and Vascular Neurology 2017;2. https://www.ncbi.nlm.nih.gov/pubmed/29507779

Fong SY, Efferth TH, Zuo Z. Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines. Expert Opin Drug Metab Toxicol. 2014 Dec;10(12):1711-39. https://www.ncbi.nlm.nih.gov/pubmed/25307559

Zhang SJ, Xue ZY. Effect of Western medicine therapy assisted by Ginkgo biloba tablet on vascular cognitive impairment of none dementia. Asian Pac J Trop Med 2012;5:661-4. https://www.ncbi.nlm.nih.gov/pubmed/22840457

Blann AD, Landray MJ, Lip GY. ABC of antithrombotic therapy: an overview of antithrombotic therapy. BMJ. 2002 Oct 5;325(7367):762-5. https://www.ncbi.nlm.nih.gov/pubmed/12364307

Fitzmaurice DA, Blann AD, Lip GY. Bleeding risks of antithrombotic therapy. BMJ. 2002 Oct 12;325(7368):828-31. https://www.ncbi.nlm.nih.gov/pubmed/12376447

Abdel-Salam OM, Baiuomy AR, El-Batran S, Arbid MS. Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat. Pharmacol Res. 2004 Feb;49(2):133-42. https://www.ncbi.nlm.nih.gov/pubmed/14643693

Chao JC, Hung HC, Chen SH, Fang CL. Effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer. World J Gastroenterol. 2004 Feb 15;10(4):560-6. https://www.ncbi.nlm.nih.gov/pubmed/14966917

Gardner CD, Zehnder JL, Rigby AJ, Nicholus JR, Farquhar JW. Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial. Blood Coagul Fibrinolysis. 2007;18:787–93. https://www.ncbi.nlm.nih.gov/pubmed/17982321

Wolf HR. Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily Drugs R D. 2006;7(3):163–172. https://www.ncbi.nlm.nih.gov/pubmed/16752942

Lim JW, Chee SX, Wong WJ, He QL, Lau TC. Traditional Chinese medicine: herb-drug interactions with aspirin. Singapore Med J. 2018 May;59(5):230-239. https://www.ncbi.nlm.nih.gov/pubmed/29796686

Vaes LP, Chyka PA. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Ann Pharmacother. 2000 Dec;34(12):1478–82. https://www.ncbi.nlm.nih.gov/pubmed/11144706

Evans V. Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use. J Neurosci Nurs. 2000 Aug;32(4):229–32. https://www.ncbi.nlm.nih.gov/pubmed/10994537 

Bebbington A, Kulkarni R, Roberts P. Ginkgo biloba: persistent bleeding after total hip arthroplasty caused by herbal self-medication. J Arthroplasty 2005;20:125-6. https://www.ncbi.nlm.nih.gov/pubmed/15660071

Martijn GH van Oijen, et al. Effect of Genetic Polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on Acetylsalicylic Acid Metabolism in Healthy Female Volunteers. Pharmacology, 83 (4), 237-42 2009. https://pubmed.ncbi.nlm.nih.gov/19262071

Loebstein R, Yonath H, Peleg D et al. Interindividual variability in sensitivity to warfarin: nature or nurture? Clin Pharmacol Ther. 2001 Aug;70(2):159-64. https://www.ncbi.nlm.nih.gov/pubmed/11503010

Wells PS, Holbrook AM, Crowther NR, Hirsh J. Interactions of warfarin with drugs and food. Ann Intern Med. 1994 Nov 1;121(9):676-83. https://www.ncbi.nlm.nih.gov/pubmed/7944078

Engelsen J, Nielsen JD, Hansen KF. [Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment: a randomized, double-blind, placebo-controlled cross over trial]. Ugeskr Laeger. 2003 Apr 28;165(18):1868-71. https://www.ncbi.nlm.nih.gov/pubmed/12772396

Lai CF, Chang CC, Fu CH, et al. Evaluation of the interaction between warfarin and ginkgo biloba extract. Pharmacotherapy. 2002;22(10):1326. Abstract No. 12. https://www.accp.com/docs/meetings/abstracts/2002_annual.pdf

Jiang X, Blair EY, McLachlan AJ. Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach. J Clin Pharmacol. 2006;46(11):1370–1378. https://www.ncbi.nlm.nih.gov/pubmed/17050802

Chua YT, Ang XL, Zhong XM, Khoo KS. Interaction between warfarin and Chinese herbal medicines. Singapore Med J. 2015 Jan;56(1):11-8. https://www.ncbi.nlm.nih.gov/pubmed/25640094

Zhou Y, Zeng R. [Effects of Ginkgo biloba extract on anticoagulation and blood drug level of warfarin in healthy wolunteers]. Zhongguo Zhong Yao Za Zhi 2011;36:2290–2293. https://www.ncbi.nlm.nih.gov/pubmed/22097347

Matthews MK. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology. 1998 Jun;50(6):1933-4. https://www.ncbi.nlm.nih.gov/pubmed/9633781

Fugh-Berman A, Ernst E. Herb-drug interactions: review and assessment of report reliability. Br J Clin Pharmacol. 2001 Nov;52(5):587-95. https://www.ncbi.nlm.nih.gov/pubmed/11736868

Kaminsky LS, et al. Human P450 Metabolism of Warfarin. Pharmacol Ther, 73 (1), 67-74 1997. https://pubmed.ncbi.nlm.nih.gov/9014207

Milić N, Milosević N, Golocorbin Kon S, Bozić T, Abenavoli L, Borrelli F. Warfarin interactions with medicinal herbs. Nat Prod Commun. 2014 Aug;9(8):1211-6. https://www.ncbi.nlm.nih.gov/pubmed/25233607 

Lamant V, Mauco G, Braquet P, Chap H, Douste-Blazy L. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochemical Pharmacology. 1987;36:2749–2752. https://www.ncbi.nlm.nih.gov/pubmed/2820421

Aruna D, Naidu M. Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects. British Journal of Clinical Pharmacology. 2007;63(3):333–338. https://www.ncbi.nlm.nih.gov/pubmed/17010102

Kim HS, Kim GY, Yeo CW, et al. The effect of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of cilostazol and its active metabolites in healthy Korean subjects. Br J Clin Pharmacol. 2014 May;77(5):821-30. https://www.ncbi.nlm.nih.gov/pubmed/24001154

Ryu KH, Han HY, Lee SY, Jeon SD, Im G-J, Lee BY, et al. Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time. Thromb Res. 2009 Jul;124(3):328–34. https://www.ncbi.nlm.nih.gov/pubmed/19349067

FDA. Cilostazol drug data. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020863s021lbl.pdf

Deng Y, Mo YF, Chen XM, Zhang LZ, Liao CF, Song Y, et al. Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats. Phytother Res. 2016 Nov;30(11):1886–92. https://www.ncbi.nlm.nih.gov/pubmed/27487816

Kim TE, Kim BH, Kim J, et al. Comparison of the pharmacokinetics of ticlopidine between administration of a combined fixed-dose tablet formulation of ticlopidine 250 mg/ginkgo extract 80 mg, and concomitant administration of ticlopidine 250-mg and ginkgo extract 80-mg tablets: an open-label, two-treatment, single-dose, randomized-sequence crossover study in healthy Korean male volunteers. Clin Ther. 2009;31(10):2249–2257. https://www.ncbi.nlm.nih.gov/pubmed/19922896

Kim BH, Kim KP, Lim KS, et al. Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers. Clinical Therapeutics. 2010;32(2):380–390. https://www.ncbi.nlm.nih.gov/pubmed/20206795

Hong JM, Shin DH, Lim YA, Lee JS, Joo IS. Ticlopidine with Ginkgo Biloba extract: a feasible combination for patients with acute cerebral ischemia. Thromb Res. 2013 Apr;131(4):e147-53. Epub 2013 Mar 7. https://www.ncbi.nlm.nih.gov/pubmed/23477707

Ha-Duong NT, et al. Ticlopidine as a Selective Mechanism-Based Inhibitor of Human Cytochrome P450 2C19. Biochemistry, 40 (40), 12112-22 2001 Oct 9. https://pubmed.ncbi.nlm.nih.gov/11580286

Kim YS, Pyo MK, Park KM, Park PH, Hahn BS, Wu SJ, et al. Antiplatelet and antithrombotic effects of a combination of ticlopidine and ginkgo biloba ext (EGb 761). Thromb Res. 1998 Jul 1;91(1):33–8. https://www.ncbi.nlm.nih.gov/pubmed/9700851

Agbabiaka TB, Wider B, Watson LK, Goodman C. Concurrent Use of Prescription Drugs and Herbal Medicinal Products in Older Adults: A Systematic Review. Drugs Aging. 2017 Dec;34(12):891-905. https://www.ncbi.nlm.nih.gov/pubmed/29196903

Meisel C, Johne A, Roots I. Fatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofen [letter]. Atherosclerosis 2003; 167: 367 https://www.ncbi.nlm.nih.gov/pubmed/12818420

Hoffman T. Ginkgo, vioxx and excessive bleeding: possible drug-herb interactions – case report [letter]. Hawaii Med J 2001; 60: 290. https://www.ncbi.nlm.nih.gov/pubmed/11797495

Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009;69(13):1777-98. https://www.ncbi.nlm.nih.gov/pubmed/19719333

Liudmila L, et al. PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015 Feb; 25(2): 96–106. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401/

Sener G, Omurtag GZ, Sehirli O, et al. Protective effects of ginkgo biloba against acetaminophen-induced toxicity in mice. Mol Cell Biochem. 2006 Feb;283(1–2):39–45. https://www.ncbi.nlm.nih.gov/pubmed/16444584

Zhang QS, Wang XP, Xie YN, et al. Protective effect of Ginkgo biloba extract on paracetamol-induced acute hepatic injury in mice. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 May 8;34(5):432-435 469. https://www.ncbi.nlm.nih.gov/pubmed/30788924

Mazaleuskaya L, et al. PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug; 25(8): 416–426. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498995/

Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing. 2001;30(6): 523–525. https://academic.oup.com/ageing/article/30/6/523/40019

Kupiec T, Raj V. Fatal seizures due to potential herb‐drug interactions with Ginkgo biloba. J Anal Toxicol 2005; 29: 755–758. https://www.ncbi.nlm.nih.gov/pubmed/16419414

Gregory PJ. Seizure associated with Ginkgo biloba? Ann Intern Med.2001;134(4):344. https://www.ncbi.nlm.nih.gov/pubmed/11182853

Bruhn JG. Scientific reporting of unscientific data--a case of Ginkgo biloba being miscredited. Phytomedicine. 2003;10(4):358. https://www.ncbi.nlm.nih.gov/pubmed/12809368

Samuels N, Finkelstein Y, Singer SR, Oberbaum M. Herbal medicine and epilepsy: Proconvulsive effects and interactions with antiepileptic drugs. Epilepsia, 2008, 49:373-380. https://www.ncbi.nlm.nih.gov/pubmed/17941846

Landmark CJ, Patsalos PN. Interactions between antiepileptic drugs and herbal medicines. Bol. Latinoam. Caribe Plant. Med. Aromaticas, 2008, Vol.7 (2). https://www.redalyc.org/pdf/856/85670209.pdf

Manocha A, Pillai KK, Husain SZ. Influence of Ginkgo biloba on the effect of anticonvulsants. Indian J Pharmacol 28, 1996. https://www.researchgate.net/publication/286702796

Leistner E, Drewke C. Ginkgo biloba and ginkgotoxin. J Nat Prod. 2010;73(1):86–92. https://www.ncbi.nlm.nih.gov/pubmed/20041670

Yang G, Wang Y, Sun J, Zhang K, Liu J. Ginkgo biloba for Mild Cognitive Impairment and Alzheimer's Disease. Curr Top Med Chem. 2016;16(5):520-8. https://www.ncbi.nlm.nih.gov/pubmed/26268332

Chen LW, Wang YQ, Wei LC, Shi M, Chan YS. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets. 2007 Aug;6(4):273-81. https://www.ncbi.nlm.nih.gov/pubmed/17691984

Cao F, Sun S, Tong E -tang. Experimental study on inhibition of neuronal toxical effect of levodopa by ginkgo biloba extract on Parkinson disease in rats. J Huazhong Univ Sci Technol Med Sci. 2003;23(2):151–3. https://www.ncbi.nlm.nih.gov/pubmed/12973934

Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J. Sex Marital Ther. 1998;24:139-143. https://www.ncbi.nlm.nih.gov/pubmed/9611693

Wheatley D. Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs. Hum Psychopharmacol. 2004 Dec;19(8):545-8. https://www.ncbi.nlm.nih.gov/pubmed/15378664

Kang BH, Lee SJ, Kim MD, et al. A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction. Hum. Psychopharm. 2002;17:279-284. https://www.ncbi.nlm.nih.gov/pubmed/12404672

Ellison JM, DeLuca P. Fluoxetine-induced genital anesthesia relieved by Ginkgo biloba extract. J. Clin. Psychiatry. 1998;59(4):199-200. https://www.ncbi.nlm.nih.gov/pubmed/9590676

Tang SW, Tang W, Leonard BE. Patients on psychotropic medications and herbal supplement combinations: clinical considerations. Int Clin Psychopharmacol. 2017 Mar;32(2):63-71. https://www.ncbi.nlm.nih.gov/pubmed/27902536

Galluzzi S, Zanetti O, Binetti G, Trabucchi M, Frisoni GB. Coma in a patient with Alzheimer’s disease taking low dose trazodone and gingko biloba. J Neurol Neurosurg Psychiatry 2000;68:679–680. https://www.ncbi.nlm.nih.gov/pubmed/10836866

Woroń J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol. 2018 Dec 29;52(6):983-996. https://www.ncbi.nlm.nih.gov/pubmed/30659561

Fowler JS, Wang GJ, Volkow ND, et al. Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain. Life Sci. 2000;66(9):PL141-PL146. https://www.ncbi.nlm.nih.gov/pubmed/10698362

Porsolt RD, Roux S, Drieu K. Evaluation of a Ginkgo biloba extract (EGb 761) in functional tests for monoamine oxidase inhibition. Arzneim.-Forsch. 2000;50(3):232-235. https://www.ncbi.nlm.nih.gov/pubmed/10758773

White HL, Scates PW, Cooper BR. Extracts of Ginkgo biloba leaves inhibit monoamine oxidase. Life Sci. 1996;58(16):1315-1321. https://www.ncbi.nlm.nih.gov/pubmed/8614288

Mills E, Wu P, Johnston BC, Gallicano K, Clarke M, Guyatt G. Natural health product-drug interactions: a systematic review of clinical trials. Ther Drug Monit. 2005 Oct;27(5):549–57. https://www.ncbi.nlm.nih.gov/pubmed/16175124 

Hemmeter U, Annen B, Bischof R, et al. Polysomnographic effects of adjuvant Ginkgo biloba therapy in patients with major depression medicated with trimipramine. Pharmacopsych. 2001;34:50-59. https://www.ncbi.nlm.nih.gov/pubmed/11302564

Chermat R, Brochet D, DeFeudis FV, Drieu K. Interactions of Ginkgo biloba extract (Egb 761), diazepam and ethyl beta-carboline-3-carboxylate on social behaviour of the rat. Pharmacol Biochem Behav, 1997, 56:333-339. https://www.ncbi.nlm.nih.gov/pubmed/9050093

Brondino N, et al. A Systematic Review and Meta-Analysis of Ginkgo biloba in Neuropsychiatric Disorders: From Ancient Tradition to Modern-Day Medicine. Evid Based Complement Alternat Med. 2013;2013:915691. https://www.ncbi.nlm.nih.gov/pubmed/23781271

Atmaca M, et al. The effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia. Psychiatry Clin Neurosci. 2005 Dec;59(6):652-6. https://www.ncbi.nlm.nih.gov/pubmed/16401239

Zhang XY, Zhou DF, Zhang PY, et al. A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia. J Clin Psychiatry. 2001 Nov;62(11):878-83. https://www.ncbi.nlm.nih.gov/pubmed/11775047

Doruk A, Uzun O, Ozşahin A. A placebo-controlled study of extract of ginkgo biloba added to clozapine in patients with treatment-resistant schizophrenia. Int Clin Psychopharmacol. 2008 Jul;23(4):223-7. https://www.ncbi.nlm.nih.gov/pubmed/18545061

Singh V, Singh SP, Chan K. Review and meta-analysis of usage of ginkgo as an adjunct therapy in chronic schizophrenia. Int J Neuropsychopharmacol. 2010 Mar;13(2):257-71. https://www.ncbi.nlm.nih.gov/pubmed/19775502

Zhang XY, Zhou DF, Su JM, et al. The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia. J Clin Psychopharmacol. 2001;21(1):85–88. https://www.ncbi.nlm.nih.gov/pubmed/11199954

Luo HC, Shen YC, Meng FQ. Therapeutic effect of shuxuening combining neuroleptics for the treatment of chronic schizophrenia – a double blind study. Zhongguo Zhong Xi Yi Jie He Za Zhi 1997;17:139–42. https://www.ncbi.nlm.nih.gov/pubmed/9863076

Knable MB. Extract of Ginkgo biloba added to haloperidol was effective for positive symptoms in refractory schizophrenia. Evid Based Ment Health. 2002 Aug;5(3):90. https://www.ncbi.nlm.nih.gov/pubmed/12180457

Chen X, Hong Y, Zheng P. Efficacy and safety of extract of Ginkgo biloba as an adjunct therapy in chronic schizophrenia: A systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. Psychiatry Res. 2015 Jul 30;228(1):121-7. https://www.ncbi.nlm.nih.gov/pubmed/25980333

Zhou D, Zhang X, Su J et al. The effects of classic antipsychotic haloperidol plus the extract of Ginkgo biloba on superoxide dismutase in patients with chronic refractory schizophrenia. Chin Med J (Engl). 1999 Dec;112(12):1093-6. https://www.ncbi.nlm.nih.gov/pubmed/11721446

Lin YY, Chu SJ, Tsai SH. Association between priapism and concurrent use of risperidone and Ginkgo biloba. Mayo Clin Proc. 2007 Oct;82(10):1289-90. https://www.mayoclinicproceedings.org/article/S0025-6196(11)61402-X/fulltext

Alsanad SM, Howard RL, Williamson EM. An assessment of the impact of herb-drug combinations used by cancer patients. BMC Complement Altern Med. 2016 Oct 18;16(1):393. https://www.ncbi.nlm.nih.gov/pubmed/27756298

An HM, Tan YL, Shi J, et al. Extract of Ginkgo biloba is equivalent to Vitamin E in attenuating and preventing vacuous chewing movements in a rat model of tardive dyskinesia. Behav Pharmacol. 2013 Oct;24(7):610-6. https://www.ncbi.nlm.nih.gov/pubmed/23994817

An HM, Tan YL, Shi J, et al. Beneficial effects of EGB761 and Vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms. Behav Brain Res. 2016 Jan 15;297:124-30. https://www.ncbi.nlm.nih.gov/pubmed/26455874

Shi J, Tan YL, Wang ZR, et al. Ginkgo biloba and Vitamin E ameliorate haloperidol-induced vacuous chewingmovement and brain-derived neurotrophic factor expression in a rat tardive dyskinesia model. Pharmacol Biochem Behav. 2016 Sep;148:53-8. https://www.ncbi.nlm.nih.gov/pubmed/27264436

An HM, Tan YL, Shi J, et al. Ginkgo biloba leaf extract and alpha-tocopherol attenuate haloperidol-induced orofacial dyskinesia in rats: Possible implication of antiapoptotic mechanisms by preventing Bcl-2 decrease and Bax elevation. Phytomedicine. 2016 Dec 1;23(13):1653-1660. https://www.ncbi.nlm.nih.gov/pubmed/27823630

Fontana L, Souza AS, Del Bel EA, Oliveira RMW de. Ginkgo biloba leaf extract (EGb 761) enhances catalepsy induced by haloperidol and L-nitroarginine in mice. Braz J Med Biol Res. 2005 Nov;38(11):1649–54. https://www.ncbi.nlm.nih.gov/pubmed/16258634

Shakibaei F, Radmanesh M, Salari E, Mahaki B. Ginkgo biloba in the treatment of attention-deficit/hyperactivity disorder in children and adolescents. A randomized, placebo-controlled, trial. Complement Ther Clin Pract. 2015 May;21(2):61-7. https://www.ncbi.nlm.nih.gov/pubmed/25925875

Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic beta-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus. J Clin Pharmacol. 2001;41(6):600–611. https://www.ncbi.nlm.nih.gov/pubmed/11402628

Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial. Drug Des Devel Ther. 2018 Apr 5;12:735-742. https://www.ncbi.nlm.nih.gov/pubmed/29670330

Kudolo GB, Wang W, Javors M, et al. The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study. Clin Nutr. 2006;25(4):606–616. https://www.ncbi.nlm.nih.gov/pubmed/16698134

Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA. Efficacy and safety of Ginkgo biloba extract as an "add-on" treatment to metformin for patients with metabolic syndrome: a pilot clinical study. Ther Clin Risk Manag. 2018 Jul 11;14:1219-1226. https://www.ncbi.nlm.nih.gov/pubmed/30034238

Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol. 2000 Jun;40(6):647-54. https://www.ncbi.nlm.nih.gov/pubmed/10868316

Kudolo GB, Wang W, Elrod R, Barrientos J, Haase A, Blodgett J. Short-term ingestion of Ginkgo biloba extract does not alter whole body insulin sensitivity in non-diabetic, pre-diabetic or type 2 diabetic subjects--a randomized double-blind placebo-controlled crossover study. Clin Nutr. 2006 Feb;25(1):123-34. Epub 2005 Nov 15. https://www.ncbi.nlm.nih.gov/pubmed/16293352

Kudolo GB. Personal communication from trial author. 29 February 2008. In Mills & Bone - Principles and practice of Phytotherapy. Modern Herbal Medicine, 2ed. Churchill Livingstone, 2013 p. 975. https://www.elsevier.com/books/principles-and-practice-of-phytotherapy/9780443069925

Wang W, Javors M, Blodgett J, et al. Effect of Ginkgo Supplement on the Pharmacokinetics of Pioglitazone in Healthy Subjects. Diabetes. 2007;56(Suppl 1):A560.

Yoshioka M, Ohnishi N, Koishi T, et al. Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of Ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers. Biol Pharm Bull. 2004 Dec;27(12):2006-9. https://www.ncbi.nlm.nih.gov/pubmed/15577221

Kubota Y, Kobayashi K, Tanaka N, et al. Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats. In Vivo. 2003;17:409–412. https://www.ncbi.nlm.nih.gov/pubmed/14598602

Dong B, Yuan S, Hu J, Yan Y. Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism. Pharm Biol. 2018 Dec;56(1):333–6. https://www.ncbi.nlm.nih.gov/pubmed/29953302

Vorberg G. Ginkgo biloba extract (GBE): A long-term study of chronic cerebral insufficiency in geriatric patients. Clin. Trials J. 1985;22(2):149-157.

Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012 Aug;42(8):784-90. https://www.ncbi.nlm.nih.gov/pubmed/22381135

Dai LL, Fan L, Wu HZ, Tan ZR, Chen Y, Peng XD, Shen MX, Yang GP, Zhou HH. Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects. Xenobiotica. 2013 Oct;43(10):862-7. https://www.ncbi.nlm.nih.gov/pubmed/23451885

Grino JM. BN 52021: A platelet activating factor antagonist for preventing post-transplant renal failure. Ann Intern Med. 1994 Sep 1;121(5):345-7. https://www.ncbi.nlm.nih.gov/pubmed/8042824

Huang XS, Liu X, Chen DZ. Effect of Ginkgo biloba extract preconditioning on discordant cardiac xenografts. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:108-11. https://www.ncbi.nlm.nih.gov/pubmed/17569363

Bagnis C, Deray G, Dubois M et al. Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist. Nephrol Dial Transplant. 1996 Mar;11(3):507-13. https://www.ncbi.nlm.nih.gov/pubmed/8671822

Barth SA, Inselmann G, Engemann R, Heidemann HT. Influences of Ginkgo biloba on cyclosporin A–induced lipid peroxidation in human liver microsomes in comparison to Vitamin E, glutathione and N-acetylcysteine. Biochem Pharmacol. 1991 May 15;41(10):1521-6. https://www.ncbi.nlm.nih.gov/pubmed/2018556

Mahmoud F, Abul H, Onadeko B, et al. In vitro effects of Ginkgolide B on lymphocyte activation in atopic asthma: comparison with cyclosporin A. Jpn J Pharmacol. 2000 Jul;83(3):241-5. https://www.ncbi.nlm.nih.gov/m/pubmed/10952073/

Naidu M, Shifow AA, Kumar KV, Ratnakar K. Ginkgo biloba extract ameliorates gentamicin-induced nephrotoxicity in rats. Phytomed. 2000;7:191-7. https://www.ncbi.nlm.nih.gov/pubmed/11185729

Wiegman DJ, Brinkman K, Franssen EJ. Interaction of Ginkgo biloba with efavirenz. AIDS. 2009;23(9):1184–1185. https://www.ncbi.nlm.nih.gov/pubmed/19451798

Blonk M, et al. Effect of ginkgo biloba on the pharmacokinetics of raltegravir in healthy volunteers. Antimicrob Agents Chemother. 2012 Oct;56(10):5070-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457394/

Fasinu PS, Gurley BJ, Walker LA. Clinically Relevant Pharmacokinetic Herb-drug Interactions in Antiretroviral Therapy. Curr Drug Metab. 2015;17(1):52-64. https://www.ncbi.nlm.nih.gov/pubmed/26526838

Li W, Zeng S, Yu LS, Zhou Q. Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management. Ther Clin Risk Manag. 2013;9:259–71. https://www.ncbi.nlm.nih.gov/pubmed/23745048

Eli R. Ginkgo biloba, may significantly reduce gastrointestinal pain: it may also reduce the risk of stomach cancer that is associated with the wide-spread use of proton pump inhibitors. Med Hypotheses. 2006;66(6):1244. https://www.ncbi.nlm.nih.gov/pubmed/16504419

Wang Q, Zhao WZ, Ma CG. Protective effects of Ginkgo biloba extract on gastric mucosa. Acta Pharmacol Sin 2000;21(12):1153–6. https://www.ncbi.nlm.nih.gov/pubmed/11603292

Karschnia P, Parsons MW, Dietrich J. Pharmacologic management of cognitive impairment induced by cancer therapy. Lancet Oncol. 2019 Feb;20(2):e92–102. https://www.ncbi.nlm.nih.gov/pubmed/30723041

Barton DL, Burger K, Novotny PJ, et al. The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9. Support Care Cancer 2013; 21: 1185–92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587364/

Hu BY, Gu YH, Cao CJ, et al. Reversal effect and mechanism of Ginkgo biloba exocarp extracts in multidrug resistance of mice S180 tumor cells. Exp Ther Med. 2016 Oct;12(4):2053–62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038854/

Hauns B, Haring B, Kohler S, et al. Phase II study with 5-fluorouracil and ginkgo biloba extract (GBE 761 ONC) in patients with pancreatic cancer. Arzneimittelforschung, 1999, 49(12), 1030-1034. https://www.ncbi.nlm.nih.gov/pubmed/10635450

Hauns B, Häring B, Köhler S, et al. Phase II study of combined 5-fluorouracil/ Ginkgo biloba extract (GBE 761 ONC) therapy in 5-fluorouracil pretreated patients with advanced colorectal cancer. Phytother Res. 2001 Feb;15(1):34–8. https://www.ncbi.nlm.nih.gov/pubmed/11180520

Chen X, Zeng L. Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression. Am J Transl Res. 2018;10(6):1773–83. https://www.ncbi.nlm.nih.gov/pubmed/30018718

Zhang Y, Chen AY, Li M, Chen C, Yao Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res. 2008 Jul;148(1):17–23. https://www.ncbi.nlm.nih.gov/pubmed/18570926

Hu WH, Chan GKL, Duan R, et al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12). https://www.mdpi.com/2072-6694/11/12/1828/htm

Dias MA, Sampaio ALL, Venosa AR, et al. The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study. Int Tinnitus J. 2015;19(2):12–9. https://www.ncbi.nlm.nih.gov/pubmed/27186927

Ozturk G, Anlar O, Erdogan E, et al. The effect of Ginkgo extract EGB761 in cisplatin-induced peripheral neuropathy in mice. Toxicol Appl Pharmacol. 2004 Apr 1;196(1):169-75. https://www.ncbi.nlm.nih.gov/pubmed/15050418

Aydin D, Peker EGG, Karakurt MD, et al. Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure. Clin Invest Med. 2016 Dec 1;39(6):27511. https://www.ncbi.nlm.nih.gov/pubmed/27917801

Amin A, Abraham C, Hamza AA, et al. A standardized extract of Ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats. J Biomed Biotechnol. 2012;2012:362049. https://www.ncbi.nlm.nih.gov/pubmed/22675250

Khafaga AF, Bayad AE. Impact of Ginkgo biloba extract on reproductive toxicity induced by single or repeated injection of cisplatin in adult male rats. International Journal of Pharmacology, 2016, 12(4), 340–350. https://www.researchgate.net/publication/301329297

Cakil B, Basar FS, Atmaca S, et al. The protective effect of Ginkgo biloba extract against experimental cisplatin ototoxicity: animal research using distortion product otoacoustic emissions. J Laryngol Otol. 2012 Nov;126(11):1097–101. https://www.ncbi.nlm.nih.gov/pubmed/22975015

Choi SJ, Kim SW, Lee JB, et al. Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication. Neuroscience. 2013 Aug 6;244:49–61. https://www.ncbi.nlm.nih.gov/pubmed/23583760

Esen E, Özdoğan F, Gürgen SG,et al. Ginkgo biloba and Lycopene are Effective on Cisplatin Induced Ototoxicity? J Int Adv Otol. 2018 Apr;14(1):22-26. https://www.ncbi.nlm.nih.gov/pubmed/28639555

Huang X, Whitworth CA, Rybak LP. Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats. Otol Neurotol. 2007 Sep;28(6):828–33. https://www.ncbi.nlm.nih.gov/pubmed/17450108

Astolfi L, Simoni E, Ciorba A, Martini A. In vitro protective effects of Ginkgo biloba against cisplatin toxicity in mouse cell line OCk3. Audiological Medicine, 2008, 6(4), 251–258. https://www.researchgate.net/publication/232052106

Fukaya H, Kanno H. [Experimental studies of the protective effect of Ginkgo biloba extract (GBE) on cisplatin-induced toxicity in rats]. Nihon Jibiinkoka Gakkai Kaiho. 1999 Jul;102(7):907-17. https://www.ncbi.nlm.nih.gov/pubmed/10459293

Okuyan B, Izzettin FV, Bingöl-Ozakpinar Ö, et al. The effects of Ginkgo biloba on nephrotoxicity induced by cisplatin-based chemotherapy protocols in rats. IUFS J Biol. 2012;71:103. http://dergipark.gov.tr/download/article-file/95640

Gulec M, Iraz M, Yilmaz HR, Ozyurt H, Temel I. The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity. Toxicol Ind Health. 2006 Apr;22(3):125–30. https://www.ncbi.nlm.nih.gov/pubmed/16716042

Inselmann G, Blöhmer A, Kottny W, et al. Modification of cisplatin-induced renal p-aminohippurate uptake alteration and lipid peroxidation by thiols, Ginkgo biloba extract, deferoxamine and torbafylline. Nephron. 1995;70(4):425–9. https://www.researchgate.net/publication/15720748

Song J, Liu D, Feng L, et al. Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity. Evid Based Complement Alternat Med. 2013;2013:846126. https://www.ncbi.nlm.nih.gov/pubmed/24371467

Liu SQ, Xu CY, Qin MB, Tan L, Zhuge CF, Mao YB, Lai MY, Huang JA. Ginkgo biloba extract enhances chemotherapy sensitivity and reverses chemoresistance through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer cells. Oncol Rep. 2015 Jun;33(6):2871-82. https://www.ncbi.nlm.nih.gov/pubmed/25962735

Ma W, Hu J, Cheng Y, Wang J, Zhang X, Xu M. Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of Akt-Nrf2-HO-1 signaling and reduction of NADPH oxidase. Cancer Chemother Pharmacol. 2015 May;75(5):949–59. https://www.ncbi.nlm.nih.gov/pubmed/25749575

Jiang W, Cong Q, Wang Y, Ye B, Xu C. Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin: Antiproliferative and Apoptosis-Inducing Effects of Ginkgolide B on Ovarian Cancer Cells. Integr Cancer Ther. 2014 May;13(3):NP10-17. https://www.ncbi.nlm.nih.gov/pubmed/22505596

Chang Z, Wang HL, Du H. Protective effect of Ginkgo flavonoids, amifostine, and leuprorelin against platinum-induced ovarian impairment in rats. Genet Mol Res. 2014 Jul 24;13(3):5276–84. https://www.ncbi.nlm.nih.gov/pubmed/25078583

Tian CJ, Kim YJ, Kim SW, et al. A combination of cilostazol and Ginkgo biloba extract protects against cisplatin-induced Cochleo-vestibular dysfunction by inhibiting the mitochondrial apoptotic and ERK pathways. Cell Death Dis. 2013 Feb 21;4:e509. https://www.ncbi.nlm.nih.gov/pubmed/23429295

Xu O, Lu H, Li P, Zhang X, Lu Z. Effect of combination of Ginkgo leaf extract and deferoxamine in preventing and treating ototoxicity of cisplatin. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):915–8. https://www.ncbi.nlm.nih.gov/pubmed/15553827

Marshall J, Zakari A, Hwang JJ, et al. Ginkgo Biloba (GB) extract as a neuroprotective agent in oxaliplatin (Ox)‐induced neuropathy. Journal of Clinical Oncology, 2004, 22(14_suppl): 3670‐3670. https://www.researchgate.net/publication/313212006

Brouwer CA, Gietema JA, van den Berg MP et al. Long-term cardiac follow-up in survivors of a malignant bone tumour. Ann Oncol. 2006 Oct;17(10):1586-91. https://www.ncbi.nlm.nih.gov/pubmed/16857723

Lucius K, Trukova K. Integrative Therapies and Cardiovascular Disease in the Breast Cancer Population: A Review, Part 1. Integr Med (Encinitas). 2015 Aug;14(4):22–9. https://www.ncbi.nlm.nih.gov/pubmed/26770154

Wu Y, Li S, Cui W, Zu X, Du J, Wang F. Ginkgo biloba extract improves coronary blood flow in healthy elderly adults: role of endothelium-dependent vasodilation. Phytomedicine. 2008;15(3):164–169. https://www.ncbi.nlm.nih.gov/pubmed/18258419

Wu Y, Li S, Cui W, Zu X, Wang F, Du J. Ginkgo biloba extract improves coronary blood flow in patients with coronary artery disease: role of endothelium-dependent vasodilation. Planta Med. 2007 Jun;73(7):624-8. Epub 2007 Jun 13. https://www.ncbi.nlm.nih.gov/pubmed/17564952

Yi SY, Nan KJ, Chen SJ. [Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jan;28(1):68-70. https://www.ncbi.nlm.nih.gov/pubmed/18418975

Naidu MU, Kumar KV, Mohan IK et al. Protective effect of Ginkgo biloba extract against doxorubicin-induced cardiotoxicity in mice. Indian J Exp Biol. 2002 Aug;40(8):894-900. https://www.ncbi.nlm.nih.gov/pubmed/12597018

Agha AM, El-Fattah AA, Al-Zuhair HH, Al-Rikabi AC. Chemopreventive effect of Ginkgo biloba extract against benzo(a)pyrene-induced forestomach carcinogenesis in mice: amelioration of doxorubicin cardiotoxicity. J Exp Clin Cancer Res. 2001 Mar;20(1):39-50. https://www.ncbi.nlm.nih.gov/pubmed/11370828

El-Boghdady NA. Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell Biochem Funct. 2013;31(4):344–351. https://pubmed.ncbi.nlm.nih.gov/23112126

Liu TJ, Yeh YC, Ting CT, et al. Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes. Cardiovasc Res. 2008;80(2):227–235. https://www.ncbi.nlm.nih.gov/pubmed/18632596

Timioğlu O, Kutsal S, Ozkur M, et al. The effect of EGb 761 on the doxorubicin cardiomyopathy. Res Commun Mol Pathol Pharmacol. 1999;106(3):181–192. https://europepmc.org/article/med/11485048

Jasim ST, Al-Kuraishy HM, Al-Gareeb AI. Gingko Biloba protects cardiomyocytes against acute doxorubicin induced cardiotoxicity by suppressing oxidative stress. J Pak Med Assoc. 2019 Aug;69(Suppl 3)(8):S103–7. https://www.ncbi.nlm.nih.gov/pubmed/31603888

El-Boghdady NA. Increased cardiac endothelin-1 and nitric oxide in adriamycin-induced acute cardiotoxicity: protective effect of Ginkgo biloba extract. Indian J Biochem Biophys. 2013;50(3):202–209. https://www.ncbi.nlm.nih.gov/pubmed/23898483

Xu Z, Wu W, Lan T, Zhang X. Protective effects of extract of Ginkgo biloba on adriamycin-induced heart failure and its mechanism: role of ghrelin peptide. Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(21):2786-9. https://www.ncbi.nlm.nih.gov/pubmed/20209916

Abd-Ellah MF, Mariee AD. Ginkgo biloba leaf extract (EGb 761) diminishes adriamycin-induced hyperlipidaemic nephrotoxicity in rats: association with nitric oxide production. Biotechnol Appl Biochem. 2007 Jan;46(Pt 1):35-40. https://www.ncbi.nlm.nih.gov/pubmed/16848766

Bekerecioğlu M, Kutluhan A, Demirtaş I, Karaayvaz M. Prevention of adriamycin-induced skin necrosis with various free radical scavengers. J Surg Res. 1998 Feb 15;75(1):61-5. https://www.ncbi.nlm.nih.gov/pubmed/9614858

Yeh YC, Liu TJ, Wang LC, et al. A standardized extract of Ginkgo biloba suppresses doxorubicin-induced oxidative stress and p53-mediated mitochondrial apoptosis in rat testes. Br J Pharmacol. 2009 Jan;156(1):48-61. https://www.ncbi.nlm.nih.gov/pubmed/19133991

Erdogan H, Fadillioglu E, Kotuk Met al. Effects of Ginkgo biloba on plasma oxidant injury induced by bleomycin in rats. Toxicology and industrial health, 2006, 22(1), 47–52. https://www.ncbi.nlm.nih.gov/pubmed/16572711

Daba MH, Abdel‐Aziz AAH, Moustafa AM, et al. Effects of L‐carnitine and Ginkgo biloba extract (EGb 761) in experimental bleomycin‐induced lung fibrosis. Pharmacological Research, 2002, 45(6), 461–467. https://www.ncbi.nlm.nih.gov/pubmed/12162946

Ben-Arye E, Samuels N, Goldstein LH, Mutafoglu K, Omran S, Schiff E, Charalambous H, Dweikat T, Ghrayeb I, Bar-Sela G, Turker I, Hassan A, Hassan E, Saad B, Nimri O, Kebudi R, Silbermann M0. Potential risks associated with traditional herbal medicine use in cancer care: A study of Middle Eastern oncology health care professionals. Cancer. 2016 Feb 15;122(4):598-610. https://www.ncbi.nlm.nih.gov/pubmed/26599199

Ben-Arye E, Samuels N, Lavie O. Integrative Medicine for Female Patients with Gynecologic Cancer. J Altern Complement Med. 2018 Sep/Oct;24(9-10):881-889. https://www.ncbi.nlm.nih.gov/pubmed/30247969

Etheridge AS, Kroll DJ, Mathews JM. Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations. J Diet Suppl 2009;6:104– 110. https://www.ncbi.nlm.nih.gov/pubmed/22435411

Vilar JB, Leite KR, Chen Chen L. Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow. Genet Mol Res. 2009 Mar 24;8(1):328-33. https://www.ncbi.nlm.nih.gov/pubmed/19440968

Almeida IV, Düsman E, Mattge GI, et al. In vivo antimutagenic activity of the medicinal plants Pfaffia glomerata (Brazilian ginseng) and Ginkgo biloba. Genet Mol Res. 2017 Sep 27;16(3). https://www.ncbi.nlm.nih.gov/pubmed/28973764

Park HJ, Lee HG, Kim YS, Lee JY, Jeon JP, Park C, et al. Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy. Anesth Analg. 2012 Nov;115(5):1228–33. https://www.ncbi.nlm.nih.gov/pubmed/23011564

Cai Z, Wang C, Liu P, Shen P, Han Y, Liu N. Ginkgo biloba extract in combination with sorafenib is clinically safe and tolerable in advanced hepatocellular carcinoma patients. Phytomedicine. 2016 Nov 15;23(12):1295–300. https://www.ncbi.nlm.nih.gov/pubmed/27765348

Park YJ, Choo WH, Kim HR, et al. Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis. Asian Pac J Cancer Prev. 2015;16(15):6317-25. https://www.ncbi.nlm.nih.gov/pubmed/26434836

Dardano A, Ballardin M, Ferdeghini M, et al. Anticlastogenic effect of Ginkgo biloba extraact in Graves' disease patients receiving radioiodine therapy. J. Clin. Endocrin. Metab. 2007;92(11):4286-4289. https://www.ncbi.nlm.nih.gov/pubmed/17711926

Dardano A, Ballardin M, Caraccio N, et al. The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with iodine-131. Thyroid. 2011;22(3):318-324. https://www.ncbi.nlm.nih.gov/pubmed/22181338

van Lonkhuizen PJC, Klaver KM, Wefel JS, et al. Interventions for cognitive problems in adults with brain cancer: A narrative review. Eur J Cancer Care (Engl). 2019 May;28(3):e13088. https://www.ncbi.nlm.nih.gov/pubmed/31090162

Attia A, Rapp SR, Case LD, et al. Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. J Neurooncol 2012; 109: 357–63. https://www.ncbi.nlm.nih.gov/pubmed/22700031

Chen HS, Zhai F, Chu YF, et al. [Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation]. Zhong Xi Yi Jie He Xue Bao. 2003 Sep;1(3):189-91. https://www.ncbi.nlm.nih.gov/pubmed/15339558

Eli R, Fasciano JA. An adjunctive preventive treatment for cancer: ultraviolet light and ginkgo biloba, together with other antioxidants, are a safe and powerful, but largely ignored, treatment option for the prevention of cancer. Med Hypotheses. 2006;66(6):1152–6. https://www.ncbi.nlm.nih.gov/pubmed/16483725

Omidkhoda SF, Razavi BM, Hosseinzadeh H. Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation: A comprehensive review. Phytother Res. 2019 Nov;33(11):2821–40. https://www.ncbi.nlm.nih.gov/pubmed/31429152

Sener G, Kabasakal L, Atasoy BM, et al. Ginkgo biloba extract protects against ionizing radiation-induced oxidative organ damage in rats. Pharmacol Res. 2006 Mar;53(3):241–52. https://www.ncbi.nlm.nih.gov/pubmed/16412663

Lin SY, Chang HP. Induction of superoxide dismutase and catalase activity in different rat tissues and protection from UVB irradiation after topical application of Ginkgo biloba extracts. Methods Find Exp Clin Pharmacol. 1997 Aug;19(6):367–71. https://www.ncbi.nlm.nih.gov/pubmed/9385585

Gevrek F, Aydin D, Ozsoy S, Aygun H, Bicer C. Inhibition by EgB761 of the effect of cellphone radiation on the male reproductive system. Bratisl Lek Listy. 2017;118(11):676–83. https://www.ncbi.nlm.nih.gov/pubmed/29216724

Ilhan A, Gurel A, Armutcu F, et al. Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. Clin Chim Acta. 2004 Feb;340(1–2):153–62. https://www.ncbi.nlm.nih.gov/pubmed/14734207

Gevrek F. Histopathological, immunohistochemical, and stereological analysis of the effect of Ginkgo biloba (EgB761) on the hippocampus of rats exposed to long-term cellphone radiation. Histol Histopathol. 2018 May;33(5):463-473. https://www.ncbi.nlm.nih.gov/pubmed/29120031

Lamproglou I, Boisserie G, Mazeron JJ, et al. Effect of Ginkgo biloba extract (EGb 761) on rats in an experimental model of acute encephalopathy after total body irradiation. Cancer Radiother. 2000 May-Jun;4(3):202-6. https://www.ncbi.nlm.nih.gov/pubmed/10897763

Yirmibesoglu E, Karahacioglu E, Kilic D, et al. The protective effects of Ginkgo biloba extract (EGb-761) on radiation-induced dermatitis: an experimental study. Clin Exp Dermatol. 2012 Jun;37(4):387–94. https://www.ncbi.nlm.nih.gov/pubmed/22211952

Chen CC, Chiang AN, Liu HN, Chang YT. EGb-761 prevents ultraviolet B-induced photoaging via inactivation of mitogen-activated protein kinases and proinflammatory cytokine expression. J Dermatol Sci. 2014 Jul;75(1):55–62. https://www.ncbi.nlm.nih.gov/pubmed/24802711

Ertekin MV, Koçer I, Karslioğlu I, et al. Effects of oral Ginkgo biloba supplementation on cataract formation and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy. Jpn J Ophthalmol. 2004 Oct;48(5):499–502. https://www.ncbi.nlm.nih.gov/pubmed/15486777

Okumus S, Taysi S, Orkmez M, et al. The effects of oral Ginkgo biloba supplementation on radiation-induced oxidative injury in the lens of rat. Pharmacogn Mag. 2011 Apr;7(26):141-5. https://www.ncbi.nlm.nih.gov/pubmed/21716624

Aricioglu A, Bozkurt M, Balabanli B, Kilinç M, Nazaroglu NK, Türközkan N. Changes in zinc levels and superoxide dismutase activities in the skin of acute, ultraviolet-B-irradiated mice after treatment with ginkgo biloba extract. Biol Trace Elem Res. 2001 May;80(2):175–9. https://www.ncbi.nlm.nih.gov/pubmed/11437182

Dumont E, Petit E, Tarrade T, Nouvelot A. UV-C irradiation-induced peroxidative degradation of microsomal fatty acids and proteins: protection by an extract of Ginkgo biloba (EGb 761). Free Radic Biol Med. 1992 Sep;13(3):197-203. https://www.ncbi.nlm.nih.gov/pubmed/1505777

El-Ghazaly MA, Sadik NAH, Rashed ER, Abd-El-Fattah AA. Neuroprotective effect of EGB761® and low-dose whole-body γ-irradiation in a rat model of Parkinson’s disease. Toxicol Ind Health. 2015 Dec;31(12):1128–43. https://www.ncbi.nlm.nih.gov/pubmed/23696346

Kim SJ. Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro. J Dermatol. 2001 Apr;28(4):193-9. https://www.ncbi.nlm.nih.gov/pubmed/11449670

Ismail AFM, El-Sonbaty SM. Fermentation enhances Ginkgo biloba protective role on gamma-irradiation induced neuroinflammatory gene expression and stress hormones in rat brain. J Photochem Photobiol B, Biol. 2016 May;158:154–63. https://www.ncbi.nlm.nih.gov/pubmed/26974576

Hedayat I, Salam OMEA, Baiuomy AR. Effect of Ginkgo biloba extract on carrageenan-induced acute local inflammation in gamma irradiated rats. Pharmazie. 2005 Aug;60(8):614–9. https://www.ncbi.nlm.nih.gov/pubmed/15325565

Ha SW, Yi CJ, Cho CK,et al. Enhancement of radiation effect by Ginkgo biloba extract in C3H mouse fibrosarcoma. Radiother Oncol. 1996 Nov;41(2):163-7. ttps://www.ncbi.nlm.nih.gov/pubmed/9004360

Hartley DE, Elsabagh S, File SE. Gincosan (a combination of Ginkgo biloba and Panax ginseng): the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women. Nutr Neurosci. 2004 Oct-Dec;7(5-6):325-33. https://www.ncbi.nlm.nih.gov/pubmed/15682929

Scholey AB, Kennedy DO. Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand. Hum Psychopharmacol. 2002 Jan;17(1):35-44. https://www.ncbi.nlm.nih.gov/pubmed/12404705

Kennedy DO, Scholey AB, Wesnes KA. Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr Neurosci. 2001;4(5):399-412. https://www.ncbi.nlm.nih.gov/pubmed/11842916

Wesnes KA, et al. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl). 2000 Nov;152(4):353-61. https://www.ncbi.nlm.nih.gov/pubmed/11140327

Wesnes KA, et al. The cognitive, subjective, and physical effects of a ginkgo biloba/Panax ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacol Bull. 1997;33(4):677-83. https://www.ncbi.nlm.nih.gov/pubmed/9493479

Ji H, Zhang G, Yue F, Zhou X. Adverse event due to a likely interaction between sodium aescinate and ginkgo biloba extract: a case report. J Clin Pharm Ther. 2017 Apr;42(2):237-238. https://www.ncbi.nlm.nih.gov/pubmed/28144968

Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol, 2006;13:e277-284. https://www.ncbi.nlm.nih.gov/pubmed/17085776

Zehra U, Tahir M, Lone KP. Ginkgo biloba induced malformations in mice. J Coll Physicians Surg Pak, 2010;20:117-121. https://www.ncbi.nlm.nih.gov/pubmed/20378040

Fernandes E, Pinto R, Reis J, et al. Effects of Ginkgo biloba extract on the embryo-fetal development in Wistar rats. Birth defects research. Part B, Developmental and reproductive toxicology, 2010;89:133-138. https://www.ncbi.nlm.nih.gov/pubmed/20437472

Pinto R, Fernandes E, Reis J, et al. Intra-uterine growth retardation after prenatal administration of Ginkgo biloba to rats. Reprod Toxicol, 2007;23:480-485. https://www.ncbi.nlm.nih.gov/pubmed/17287108

De Faria D, Borges L, Peters V, et al. Postnatal development of pups from nursing rats treated with Ginkgo biloba. Phytother Res, 2008;22:185-189. https://www.ncbi.nlm.nih.gov/pubmed/17726727


 

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