שיפור קוגניטיבי:

99. Wattanthorn, J., Mator L., Muchimapura S., et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. Journal of Ethnopharmacology, 2008;116(2): 325-332. https://www.ncbi.nlm.nih.gov/pubmed/18191355.

100. Dev RDO, Mohamed S, Hambali Z, Samah BA. Comparison on cognitive effects of Centella asiatica in healthy middle age female and male volunteers. European Journal of Scientific Research. 2009;31(4):553–565. https://www.ncbi.nlm.nih.gov/pubmed/18191355.

101. Tiwari S, Singh S, Patwardhan K, Gehlot S, Gambhir IS. Effect of Centella asiatica on mild cognitive impairment (MCI) and other common age-related clinical problems. Digest Journal of Nanomaterials and Biostructures. 2008;3:215–220. https://www.researchgate.net/profile/Kishor_Patwardhan/publication/201910063

102. Farhana KM, Malueka RG, Wibowo S, Gofir A. Effectiveness of Gotu Kola extract 750 mg and 1000 mg compared with Folic acid 3 mg in improving vascular cognitive impairment after stroke. Evidenace Based Complementary Alternative Medicine, 2016. https://www.ncbi.nlm.nih.gov/pubmed/27340413.

103. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preperation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Journal of Attention Disorders, Nov. 2010;14(3): 281-291. https://www.ncbi.nlm.nih.gov/pubmed/20228219.

מקורות מחקריים:

[1] Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins.
[2] Wiesława Bylka, Paulina Znajdek-Awiżeń et al. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013 Feb; 30(1): 46–49. PMID: 24278045. DOI: 10.5114/pdia.2013.33378.
[3] attanathorn J. Mator L. Muchimapura S. et al. Positive modulation of cognition and mood in healthy elderly volunteer following the administration of Centella asiatica. J. Ethnopharmacol. 2008, 116: 325-332.
[4] Jerome Sarris, Erica McIntyre et al. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. PMID: 23653088. DOI: 10.1007/s40263-013-0059-9

[5] Mengalan S. Watson MF. Centella L. in: Flora of China, 2005, 14:18 DerMarderosian A. Beutler J. eds. The Review of Natural Products. St. Louis, MO: Facts and Comparisons, 2002.
[6] Plant Cures website. Premilla MS. Ayurvedic Herbs: A Clinical Guide to the Healing Plants of Traditional Indian Medicine.

שיקום העור

149. Haftek M, Mac-Mary S, Le Bitoux MA, et al. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp Dermatol. 2008;17(11):946-52. https://www.ncbi.nlm.nih.gov/pubmed/18503551.

10. Bossé JP, Papillon J, Frenette G, Dansereau J, Cadotte M, Le Lorier J. Clinical study of a new antikeloid agent. Ann Plast Surg. 1979 Jul;3(1):13-21. https://www.ncbi.nlm.nih.gov/pubmed/396846.

150. Cotellese R, Hu S, Belcaro G, Ledda A, et al. Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids. Minerva Chir. 2018;73(2):151-156. https://www.ncbi.nlm.nih.gov/pubmed/29623705.

151. Jenwitheesuk K, Rojsanga P, Chowchuen B, Surakunprapha P. A Prospective Randomized, Controlled, Double-Blind Trial of the Efficacy Using Centella Cream for Scar Improvement. Evid Based Complement Alternat Med. 2018:9525624. https://www.ncbi.nlm.nih.gov/pubmed/30310413.

152. Kircik LH. Comparative study of the Efficacy and tolerability of a unique topical scar product vs. white petrolatum following shave biopsies. J Drugs Dermatol. 2013;12(1):86-90. https://www.ncbi.nlm.nih.gov/pubmed/23377333.

153. Hu S, Belcaro G, Hosoi M, et al. Postpartum stretchmarks: repairing activity of an oral Centella asiatica supplementation (Centellicum®). Minerva Ginecol. 2018 Oct;70(5):629-634. https://www.ncbi.nlm.nih.gov/pubmed/30293400.

154. García Hernández JÁ, et al. Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial. Int J Cosmet Sci. (2013). https://www.ncbi.nlm.nih.gov/pubmed/23237514.

155. Draelos ZD, Gold MH, Kaur M, Olayinka B, Grundy SL, Pappert EJ, Hardas B. Evaluation of an onion extract, Centella asiatica, and hyaluronic acid cream in the appearance of striae rubra. Skinmed. 2010 Mar-Apr;8(2):80-6. https://www.ncbi.nlm.nih.gov/pubmed/20527138.

156. Mallol J, et al. Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci. (1991). https://www.ncbi.nlm.nih.gov/pubmed/19291041.

157. Rossi AB, Vergnanini AL. Cellulite: a review. J Eur Acad Dermatol Venereol. 2000;14(4):251-62. https://www.ncbi.nlm.nih.gov/pubmed/11204512.

158. Hachem A & Borgoin JY. Étude anatomo – clinique des effets de l’extrait titré de centella asiatica dans la lipodystrophie localisée. La Méd Prat 1979; 12(4): 17–21.

47. Mills S, Bone K. Principles and practice of Phytotherapy. Modern Herbal Medicine, 2ed. Churchill Livingstone, 2013. https://www.elsevier.com/books/principles-and-practice-of-phytotherapy/9780443069925.

161. Savai J, Varghese A, Pandita N, Chintamaneni M. In vitro assessment of CYP1A2 and 2C9 inhibition potential of Withania somnifera and Centella asiatica in human liver microsomes. Drug Metabol Personal Ther. 2015 May 1. https://www.ncbi.nlm.nih.gov/pubmed/25938222.

סוּכרת ואיזון שומני הדם

185. Mutayabarwa C, Sayi J, Dande M. Hypoglycaemic activity of Centella asiatica (L) Urb. East and central African Journal of Pharmaceutical Sciences. 2005;6(2):30–35. https://www.ajol.info/index.php/ecajps/article/view/9696.

186. Chauhan P K, Pandev I P, Dhatwalia V K. Evaluation of the antidiabetic effect of ethanolic and methanolic extracts of Centella asiatica leaves extract on alloxan induced diabetic rats. Advances in Biological Research, 2010;4(1), 27-30. https://www.researchgate.net/publication/267699746

187. Rao M. L. V. G, Mastan S. A. Antidiabetic effects of methanolic extract of Centella asiatica (Linn.) on induced hyperglycemic rats. Biosci Biotechnol Res Asia 2007;4(2). http://www.biotech-asia.org/vol4no2/antidiabetic-effects-of-methanolic-extract-of-centella-asiatica-linn-on-induced-hyperglycemic-rats/.

188. Kabir AU, Samad MB, D'Costa NM, et al. Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding. BMC Complement Altern Med. 2014;14:31. https://www.ncbi.nlm.nih.gov/pubmed/24438380.

189. Ramachandran V, Saravanan R, Senthilraja P. Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches. Phytomedicine. 2014;21(3):225-32. https://www.ncbi.nlm.nih.gov/pubmed/24075211.

ויסות חיסוני

217. Somchit MN, Sulaiman MR, Zuraini A, et al. Antinociceptive and antiinflammatory effects of Centella asiatica. Indian J Pharmacol. 2004;36(6): 377–380. http://medind.nic.in/ibi/t04/i6/ibit04i6p377.pdf.

218. Punturee K, Wild CP, Kasinrerk W, Vinitketkumnuen U. Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts. Asian Pac J Cancer Prev. 2005;6(3):396-400. https://www.ncbi.nlm.nih.gov/pubmed/16236006.

219. Patil JS, Nagavi BG, Ramesh M, et al. A study on the immunostimulant activity of Centella asiatica Linn in rats. Ind Drugs. 1998;38:711–714. https://www.researchgate.net/publication/286738471

220. Jayathirtha MG, Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine. 2004;11(4):361-5. https://www.ncbi.nlm.nih.gov/pubmed/15185851.

221. George M, Joseph L, Ramaswamy. Anti-allergic, anti-pruritic and anti-inflammatory activities of Centella asiatica extracts. African J Tradit Complement Altern Med. 2009;6(4):554–559. https://www.ncbi.nlm.nih.gov/pubmed/20606777.

222. Yun KJ, Kim JY, Kim JB, et al. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Int Immunopharmacol. 2008;8:431–441. https://www.ncbi.nlm.nih.gov/pubmed/18279797.

223. Won JH, Shin JS, Park HJ, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010;76(3):251–257. https://www.ncbi.nlm.nih.gov/pubmed/19774506.

224. Huang SS, Chiu CS, Chen HJ, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857. https://www.ncbi.nlm.nih.gov/pubmed/21584194.

מחלות וכלי דם

67. Martinez-Zapata MJ, Vernooij RW, Uriona Tuma SM, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016 Apr 6;4:CD003229. https://www.ncbi.nlm.nih.gov/pubmed/27048768.

68. Allegra C, Pollari G, Criscuolo A, et al. Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placebo. Clin Ter 1981;99:507-513. [Article in Italian]. https://www.ncbi.nlm.nih.gov/pubmed/7037273.

69. Pointel JP, Boccalon H, Cloarec M, Ledevehat C, Joubert M. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology. 1987 Jan;38(1 Pt 1):46-50. https://www.ncbi.nlm.nih.gov/pubmed/3544968.

70. Chong NJ, Aziz Z. A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency. Evid Based Complement Alternat Med. 2013;2013:627182. https://www.ncbi.nlm.nih.gov/pubmed/23533507.

71. Cesarone MR, Laurora G, De Sanctis MT, Belcaro G. Activity of Centella asiatica in venous insufficiency. Minerva Cardioangiol. 1992 Apr;40(4):137-43. https://www.ncbi.nlm.nih.gov/pubmed/1528498.

72. Cesarone MR, Belcaro G, Rulo A, et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. Angiology. 2001 Oct;52 Suppl 2:S45-8. https://www.ncbi.nlm.nih.gov/pubmed/11666123.

73. Incandela L, Belcaro G, De Sanctis MT, et al. Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model. Angiology. 2001 Oct;52 Suppl 2:S61-7. https://www.ncbi.nlm.nih.gov/pubmed/11666126.

74. De Sanctis MT, Belcaro G, Incandela L, et al. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology. 2001 Oct;52 Suppl 2:S55-9. https://www.ncbi.nlm.nih.gov/pubmed/11666125.

75. Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA. Angiology. 1990 Jan;41(1):12-8. https://www.ncbi.nlm.nih.gov/pubmed/2305995.

76. Cesarone MR, Laurora G, De Sanctis MT, et al. The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study. Minerva Cardioangiol. 1994 Jun;42(6):299-304. https://www.ncbi.nlm.nih.gov/pubmed/7936334.

77. Belcaro GV, Grimaldi R, Guidi G. Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA. Angiology. 1990 Jul;41(7):533-40. https://www.ncbi.nlm.nih.gov/pubmed/2389834.

78. Cesarone MR, Belcaro G, De Sanctis MT, et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology. 2001 Oct;52 Suppl 2:S15-18. https://www.ncbi.nlm.nih.gov/pubmed/11666117.

79. De Sanctis MT, Incandela L, Cesarone MR, et al. Acute effects of TTFCA on capillary filtration in severe venous hypertension. Panminerva Med. 1994 Jun;36(2):87-90. https://www.ncbi.nlm.nih.gov/pubmed/7831065.

ריפוי כיבים פפטיים

41. Cho KH, Chung TJ, Kim SJ, Lee TH, Yoon CM. Clinical experiences of Madecassol (Centella asiatica) in the treatment of Peptic Ulcer. The Korean Journal of Gastroenthrology, 1981,13(1): 49-56. http://indianmedicine.eldoc.ub.rug.nl/37098/.

ריפוי פּצעים וכיבים