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  1. דף הבית
  2. מחקרים
  3. פיטריית היריסיום מחקרים
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  2. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010;31:231–7.
  3. Operational guidance: Information needed to support clinical trials of herbal products. https://www.who.int/tdr/ publications/documents/operational-guidance-eng.pdf.
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  6. Wong KH, Naidu M, David P, et al. Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011;2011:580752.
  7. Tanaka A, Matsuda H. Expression of nerve growth factor in itchy skins of atopic NC/NgaTnd mice. J Vet Med Sci. 2005;67:915–9.
  8. Nakatsugawa M, Takahashi H, Takezawa C, et al. Hericium erinaceum (yamabushitake) extract-induced acute respiratory distress syndrome monitored by serum surfactant proteins. Intern Med. 2003;42:1219–22.
  9. Kawagishi H., Ando M., Sakamoto H., et al. Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum. Tetrahedron Letters. 1991;32(35):4561–4564. doi: 10.1016/0040-4039(91)80039-9.
  10. Kawagishi H., Ando M., Shinba K., et al. Chromans, hericenones F, G and H from the mushroom Hericium erinaceum. Phytochemistry. 1992;32(1):175–178. doi: 10.1016/0031-9422(92)80127-Z.
  11. Kawagishi H., Shimada A., Shirai R., et al. Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Letters. 1994;35(10):1569–1572. doi: 10.1016/S0040-4039(00)76760-8.
  12. Kawagishi H., Shimada A., Hosokawa S., et al. Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Letters. 1996;37(41):7399–7402. doi: 10.1016/0040-4039(96)01687-5.
  13. Kawagishi H., Simada A., Shizuki K., et al. Erinacine D, a stimulator of NGF-synthesis, from the mycelia of Hericium erinaceum. Heterocyclic Communications. 1996;2(1) doi: 10.1515/HC.1996.2.1.51.
  14. Lee E. W., Shizuki K., Hosokawa S., et al. Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum. Bioscience, Biotechnology, and Biochemistry. 2000;64(11):2402–2405. doi: 10.1271/bbb.64.2402.
  15. Mori K., Inatomi S., Ouchi K., Azumi Y., Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research. 2009;23(3):367–372. doi: 10.1002/ptr.2634.
  16. Mori K., Obara Y., Hirota M., et al. Nerve growth factor-inducing activity of Hericium erinaceusin 1321N1 human astrocytoma cells. Biological & Pharmaceutical Bulletin. 2008;31(9):1727–1732. doi: 10.1248/bpb.31.1727.
  17. Chen C.-C., Tzeng T. T., Chen C. C., et al. Erinacine S, a rare sesterterpene from the mycelia of Hericium erinaceus. Journal of Natural Products. 2016;79(2):438–441. doi: 10.1021/acs.jnatprod.5b00474.
  18. Lu C.-C., Huang W. S., Lee K. F., et al. Inhibitory effect of erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21. Journal of Functional Foods. 2016;21:474–484. doi: 10.1016/j.jff.2015.12.031.
  19. Tzeng T. T., Chen C. C., Chen C. C., et al. The cyanthin diterpenoid and sesterterpene constituents of Hericium erinaceusmycelium ameliorate Alzheimer’s disease-related pathologies in APP/PS1 transgenic mice. International Journal of Molecular Sciences. 2018;19(2) doi: 10.3390/ijms19020598.
  20. aito T., Aoki F., Hirai H., et al. Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum. The Journal of Antibiotics. 1998;51(11):983–990. doi: 10.7164/antibiotics.51.983.
  21. Lee K. F., Chen J. H., Teng C. C., et al. Protective effects of Hericium erinaceusmycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. International Journal of Molecular Sciences. 2014;15(9):15073–15089. doi: 10.3390/ijms150915073.
  22. Ma B. J., Shen J. W., Yu H. Y., Ruan Y., Wu T. T., Zhao X. Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycology. 2010;1(2):92–98. doi: 10.1080/21501201003735556.
  23. Krzyczkowski W., Malinowska E., Herold F. Erinacine A biosynthesis in submerged cultivation of Hericium erinaceum: quantification and improved cultivation. Engineering in Life Sciences. 2010;10(5):446–457. doi: 10.1002/elsc.201000084.
  24. Li I. C., Chen Y. L., Lee L. Y., et al. Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceusin a 28-day oral feeding study in Sprague-Dawley rats. Food and Chemical Toxicology. 2014;70:61–67. doi: 10.1016/j.fct.2014.04.040.
  25. Wolters N., Schembecker G., Merz J. Erinacine C: a novel approach to produce the secondary metabolite by submerged cultivation of Hericium erinaceus. Fungal Biology. 2015;119(12):1334–1344. doi: 10.1016/j.funbio.2015.10.005.
  26. Kuo H. C., Lu C. C., Shen C. H., et al. Hericium erinaceusmycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. Journal of Translational Medicine. 2016;14(1):p. 78. doi: 10.1186/s12967-016-0831-y.
  27. Tsai-Teng T., Chin-Chu C., Li-Ya L., et al. Erinacine A-enriched Hericium erinaceusmycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. Journal of Biomedical Science. 2016;23(1):p. 49. doi: 10.1186/s12929-016-0266-z.
  28. Chiu C.-H., Chyau C. C., Chen C. C., et al. Erinacine A-enriched Hericium erinaceusmycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular Sciences. 2018;19(2):p. 341. doi: 10.3390/ijms19020341.
  29. Liu P. S., Chueh S. H., Chen C. C., Lee L. Y., Shiu L. Y. Lion’s mane medicinal mushroom, Hericium erinaceus(Agaricomycetes), modulates purinoceptor-coupled calcium signaling and murine nociceptive behavior. International Journal of Medicinal Mushrooms. 2017;19(6):499–507. doi: 10.1615/IntJMedMushrooms.v19.i6.20.
  30. Li I. C., Chen W. P., Chen Y. P., Lee L. Y., Tsai Y. T., Chen C. C. Acute and developmental toxicity assessment of erincine A-enriched Hericium erinaceusmycelia in Sprague-Dawley rats. Drug and Chemical Toxicology. 2018:1–6. doi: 10.1080/01480545.2017.1381110.
  31. Li I. C., Chen Y. L., Chen W. P., et al. Genotoxicity profile of erinacine A-enriched Hericium erinaceusToxicology Reports. 2014;1:1195–1201. doi: 10.1016/j.toxrep.2014.11.009.
  32. Chen C.-C. In the 14th Asian Consortium for the Conservation and Sustainable Use of Microbial Resources. National Taiwan University Hospital International Convention Center; 2017. Neurohealth manifestations rendered by erinacine-A enriched Hericium erinaceus

מקורות מחקריים:

  1. I-Chen Li, Li-Ya Lee, Tsai-Teng Tzeng, Wan-Ping Chen, Yen-Po Chen, Young-Ju Shiao,  Chin-Chu Chen. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacin
  2. Behav Neurol. 2018; 2018: 5802634. Published online 2018 May 21. doi: 1155/2018/5802634.
  3. Liu PS, Chueh SH, Chen CC, Lee LY, Shiu LY. Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Modulates Purinoceptor-Coupled Calcium Signaling and Murine Nociceptive Behavior. Int J Med Mushrooms. 2017;19(6):499-507. Doi: 0.1615/IntJMedMushrooms.v19.i6.20
  4. Hobbs C. Medicinal Mushrooms, 3rd edn. Santa Cruz: Botanica Press; 1995. 2. Zhou J, Xie G, Yan X. Encyclopedia of Molecular Structures, Pharmacological Activities, Natural Sources and Applications Traditional Chinese Medicines Vol. 5: Isolated Compounds T–Z. Berlin Heidelberg: SpringerVerlag; 2011.
  5. Kwagishi H, Shimada A, Shirai R, et al. Erinacines A, B and C strong stimulators of nerve growth factor (NGF)- synthesis from the mycelia of Hericium erinaceum. Tetrahedron Lett. 1994;35:1569–72.
  6. Shen JW, Yu HY, Ruan Y, et al. Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycol Int J Fungal Biol. 210;1:92–8.
  7. Mizuno T, Wasa T, Ito H, et al. Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called Yamabushitake or Houtou. Biosci Biotechnol Biochem. 1992;56:347–8.
  8. He X, Wang X, Fang J, et al. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: a review. Int J Biol Macromol. 2017;97:228–37.
  9. Cheng JH, Tsai CL, Lien YY, et al. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016;16:170.
  10. Cui F, Gao X, Zhang J, et al. Protective effects of extracellular and intracellular polysaccharides on hepatotoxicity by Hericium erinaceus SG-02. Curr Microbiol. 2016;73(3):379–85.
  11. Liu J, Du C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Exp Ther Med. 2015;9(2):483–7.
  12. Thongbai B, Rapior S, Hyde KD, et al. Hericium erinaceus, an amazing medicinal mushroom. Mycol Progress. 2015;14:91.
  13. Wang K, Bao L, Qi Q, et al. Erinacerins C-L, isoindolin1-ones with alpha-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J Nat Prod. 2015;78(1);146–54.
  14. Moldavan MG, Gryganski AP, Kolotushkina OV, et al. Neurotropic and trophic action of lion’s mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) extracts on nerve cells in vitro. Int J Med Mushrooms. 2007;9:15–28.
  15. Li JL, Lu L, Dai CC, et al. A comparative study on sterols of ethanol extract and water extract from Hericium erinaceus. Zhongguo Zhong Yao Za Zhi. 2001;26:831−4.
  16. Abdullah N, Ismail SM, Aminudin N, et al. Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evid Based Complement Alternat Med. 2012 (2012), Article ID 464238, 12 pages. https://dx.doi.org/10.1155/2012/464238.
  17. Gershenzon J, Dudareva N. The function of terpene natural products in the natural world. Nat Chem Biol. 2007;3(7):408–14.
  18. Chappell J. The genetics and molecular genetics of terpene and sterol origami. Curr Opin Plant Biol. 2002;5(2):151–7.
  19. Guillamón E, García-Lafuente A, Lozano M, et al. Edible mushrooms: role in the prevention of cardiovascular diseases. Fitoterapia. 2010;81(7):715–23.
  20. Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion’s mane mushroom). BioMed Res Int. 2014;2014:828149. doi:10.1155/2014/828149.
  21. Lee KF, Chen JH, Teng CC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014;15(9):15073–89.
  22. Yaoita Y, Kakuda R, Machida K, et al. Ceramide constituents from five mushrooms. Chem Pharmaceut Bull. 2002;50(5):551–3.
  23. Mori K, Obara Y, Hirota M, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008;31:1727–32.
  24. Mori K, Obara Y, Moriya T, et al. Effects of Hericium erinaceus on amyloid beta(25–35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32(1):67–72.
  25. Tzeng TT, Chen CC, Lee LY, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016;23:49.
  26. Trovato A, Siracusa R, Di Paola R, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Hericium erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis. Immun Ageing. 2016;13:23.
  27. Zhang J, An S, Hu W, et al. The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer’s disease mouse model. Int J Mol Sci. 2016;17(11);1810.
  28. Kuo HC, Lu CC, Shen CH, et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Translat Med. 2016;14:78.
  29. Wong KH, Naidu M, David RP, et al. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). Int J Med Mushrooms. 2012;14(5):427–46.
  30. Mori K, Inatomi S, Ouchi K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a doubleblind placebo-controlled clinical trial. Phytother Res. 2009;23:367–72.

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